聚醚醚酮口腔生物复合材料的制备及性能研究

发布时间：2018-06-10 01:51

本文选题：聚醚醚酮 + 钡玻璃粉　；参考：《吉林大学》2013年博士论文

【摘要】：聚醚醚酮（PEEK）具有良好的力学性能、化学稳定性和生物相容性，可耐受高温蒸汽和辐照消毒，这些优良的特性使PEEK制成的椎间融合器材料获得广泛的临床使用。然而，由于PEEK难以与市场上常见的口腔材料进行良好的粘接，而且无法进行术后的X射线检验，热膨胀系数牙齿相差较大，目前在口腔领域中，PEEK仅作为临时冠材料被少量应用。为了使PEEK在口腔领域获得更加广泛的应用，本论文以改善PEEK材料力学性能、粘接性能、热膨胀性能、X射线阻射性能和生物活性为目的，通过共混和表面涂层的手段，对PEEK材料进行了改性。首先，我们利用共混方式，通过改变钡玻璃粉（BGF）的含量和粒径，制备出了一系列聚醚醚酮/钡玻璃粉（PEEK/BGF）复合材料。经研究表明，随着BGF填充含量的提高，材料与树脂水门汀的粘接强度、X射线阻射性能都得到显著的提高，材料的热膨胀性能、力学性能和耐磨性也得到一定的改善。在粘接测试中，1μm粒径的BGF制备复合材料与树脂水门汀的粘接强度较高，随着填料含量增加，粘接强度随之增大。通过不同的处理方法，证实了材料与树脂水门汀粘接的改善来源于BGF的充填。通过添加BGF，材料和摩擦面的真实接触面积降低，，使得摩擦系数明显下降。之后，通过二次双螺杆挤出制备了不同填料比例的聚醚醚酮/钡玻璃粉/玻璃纤维三元共混复合材料。玻纤的增强使材料的模量、热膨胀性能和耐磨性得到进一步提高。为了改善材料的生物活性，本文使用了两种方法将具有生物活性的纳米羟基磷灰石(nHA)引入PEEK体系。方法一，使用熔融共混的方式制备了聚醚醚酮/纳米羟基磷灰石(PEEK/nHA)复合材料。nHA的充填提高了材料的力学性能，但是材料的表面生物活性却没有得到明显改善。通过表面元素分析证实，材料表面暴露的纳米羟基磷灰石较少，可能是导致生物活性没有明显改善的主要原因。方法二，通过使用硅烷偶联剂的方法，在PEEK/BGF复合材料表面构建光固化涂层。涂层由具有生物活性的纳米羟基磷灰石（nHA）和甲基丙烯酸酯类光固化树脂复合而成。研究结果表明, nHA填充的光固化涂层使材料表面的生物活性得到提高。
[Abstract]:Polyether ether ketone (PEEK) has good mechanical properties, chemical stability and biocompatibility, and can withstand high temperature steam and irradiation disinfection. These excellent properties make PEEK interbody fusion cage material widely used in clinic. However, because peek is difficult to bond well with the common oral materials in the market and can not be examined by X-ray after operation, the coefficient of thermal expansion of teeth is quite different. At present, peek is only used as a temporary crown material in the field of stomatology. In order to obtain more extensive application of peek in the field of stomatology, the purpose of this paper is to improve the mechanical properties, adhesive properties, thermal expansion properties and X-ray resistance of peek materials. Firstly, a series of polyether ether ketone / barium glass powder PEEK / BGF composites were prepared by changing the content and particle size of barium glass powder. The results show that with the increase of the content of BGF, the bonding strength and X-ray resistance of the materials to the resin cement are improved significantly, and the thermal expansion, mechanical properties and wear resistance of the materials are also improved to a certain extent. The adhesive strength of the composite prepared with 1 渭 m diameter BGF was higher than that of the resin cement, and the bonding strength increased with the increase of filler content. Through different treatment methods, it is proved that the improvement of the bonding between the material and the resin cement comes from the filling of BGF. By adding BGF, the real contact area between the material and the friction surface is decreased, and the friction coefficient is obviously decreased. After that, polyether ether ketone / barium glass powder / glass fiber ternary composites with different filler ratios were prepared by twin-screw extrusion. In order to improve the bioactivity of the materials, two methods were used to introduce bioactive nano-hydroxyapatite into peek system. Methods 1. The filling of polyether ether ketone / nano-hydroxyapatite (PEEK / nHA) composite by melt blending improved the mechanical properties of the composite, but the surface biological activity of the composite was not obviously improved. The results of surface elemental analysis show that the low exposure of nano-hydroxyapatite on the surface of the material may be the main reason for the lack of significant improvement in biological activity. Secondly, the photocuring coating was constructed on the surface of PEEK / BGF composite by using silane coupling agent. The coating is composed of nano-hydroxyapatite with bioactivity and light curing resin of methacrylate. The results showed that the surface bioactivity of NHA-filled coatings was improved.
【学位授予单位】：吉林大学
【学位级别】：博士
【学位授予年份】：2013
【分类号】：R783.1

【参考文献】