基于有效探测区域的频域内窥式漫射层析成像系统

发布时间：2019-02-14 15:01

【摘要】：内窥式漫射层析成像(EDOT)在内部器官癌症的早期诊断方面具有很大潜力,基于本课题组提出的有效探测区域(EDR)方法,发展了基于EDR的频域EDOT系统.首先,为了实现EDR测量模式并简化测量系统,研制了仅利用两根光纤的旋转探头;其次,研制了频域EDOT检测系统,发展了基于EDR的图像重构算法;最后,在固体仿体和管状生物组织上进行了实验验证.固体仿体重构结果表明:重构异质体的大小和位置均同固体仿体目标相同,双异质体可被清晰分开,且吸收和约化散射系数的量化率(QR)分别可达到25%和20%以上;管状生物组织的重构结果表明,重构异质体的位置正确,且重构出的吸收系数和约化散射系数的QR值分别可达到25.3%和18.7%.
[Abstract]:Endoscope diffuse tomography (EDOT) has great potential in early diagnosis of internal organ cancer. A frequency-domain EDOT system based on EDR is developed based on the effective region detection (EDR) method proposed by our team. Firstly, in order to realize the EDR measurement mode and simplify the measurement system, a rotating probe using only two optical fibers is developed. Secondly, the frequency-domain EDOT detection system is developed, and the image reconstruction algorithm based on EDR is developed. Finally, experiments were carried out on solid imitators and tubular tissues. The results show that the size and position of the reconstructed heterostructures are the same as the targets of the solid imitators, the double heterostructures can be clearly separated, and the quantization rates of absorption and reduced scattering coefficients can reach more than 25% and 20% respectively. The reconstruction results of tubular biological tissue show that the reconstructed heterogeneity is in the correct position, and the QR values of the reconstructed absorption coefficient and reduced scattering coefficient can reach 25.3% and 18.7%, respectively.
【作者单位】：天津大学精密仪器与光电子工程学院;天津市生物医学检测技术与仪器重点实验室;
【基金】：国家自然科学基金资助项目(81271618,30970775,81101106,61108081) 天津市自然科学基金资助项目(12JCQNJC09400)
【分类号】：R310

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