琼脂糖在组织工程中的研究进展

发布时间：2019-04-29 09:12

【摘要】：琼脂糖是一种来源丰富、成本低廉的天然高分子材料,具有生物安全性和可降解性,利用其凝胶化现象可制成形状可塑的具有三维网络结构的凝胶。与其他天然材料相比,琼脂糖凝胶在机械性能上具有一定优势,如抗拉伸/压缩性、粘弹性、流变性等。其特殊的防粘连作用,使其必须与其他材料复合或者选用适宜的定型方式制成组织工程支架,以提高支架的组织相容性,用于填充、修复或者再生机体缺损组织。琼脂糖在组织工程领域的研究历史虽然不长,但在软骨、神经、骨、角膜和口腔黏膜等方面已经取得一些研究成果,其独特的微观结构和力学性能使其在软骨组织工程方面的研究最为广泛。目前,琼脂糖的组织工程研究离临床应用还有一段距离,材料制备和作用机理探索将是未来研究的重点。
[Abstract]:Agarose is a kind of natural polymer material with rich source and low cost. It has biological safety and biodegradability. The gelation phenomenon of agarose can be used to form a shape-plastic gel with three-dimensional network structure. Compared with other natural materials, agarose gel has some advantages in mechanical properties, such as tensile / compressibility, viscoelasticity, rheological property and so on. Because of its special anti-adhesion effect, it must be combined with other materials or made into tissue engineering scaffolds in order to improve the tissue compatibility of the scaffolds, which can be used to fill, repair or regenerate the defect tissue of the body. Although the research history of agarose in the field of tissue engineering is not long, some achievements have been made in cartilage, nerve, bone, cornea and oral mucosa. Its unique microstructure and mechanical properties make it the most widely studied in cartilage tissue engineering. At present, the research on tissue engineering of agarose is still a long way from clinical application, and the preparation of materials and the exploration of mechanism of action will be the focus of future research.
【作者单位】：广州创尔生物技术股份有限公司;暨南大学生命科学技术学院;
【基金】：广东省海洋经济创新发展区域示范专项(GD2012-B03-002) 广东省科技计划项目(2012B070800007)资助项目
【分类号】：R318.08

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