正交优化白及多糖复合支架材料的实验研究
发布时间：2019-06-29 16:12
【摘要】：目的研究制备用于骨组织工程再生的白及多糖复合支架材料,采用正交实验的方法优化最佳配比。方法将纯化的白及多糖用高碘酸钠氧化改性,并与羟丙基壳聚糖和纳米珍珠层粉共混,冷冻干燥法得到复合支架材料,测试材料性能。结果研究制备出白及多糖复合支架材料并得出最优比例,支架材料各项指标符合组织工程要求。结论成功用正交分析方法优化了白及多糖复合支架材料,为其进一步研究提供了理论依据,有望成为新型组织工程生物支架材料。
[Abstract]:Objective to study the preparation of white and polysaccharide composite scaffolds for bone tissue engineering regeneration and to optimize the optimum proportion by orthogonal experiment. Methods the purified white and polysaccharide were oxidized and modified by sodium periodate and mixed with hydroxypropyl chitosan and nano-pearl layer powder. The composite scaffolds were prepared by freeze-drying method and the properties of the materials were tested. Results White and polysaccharide composite scaffolds were prepared and the optimal proportion was obtained. the indexes of scaffolds met the requirements of tissue engineering. Conclusion the composite scaffold material of Baihe polysaccharide was successfully optimized by orthogonal analysis, which provided a theoretical basis for its further study and was expected to become a new type of tissue engineering biological scaffold material.
【作者单位】： 山东大学口腔医学院牙周科山东省口腔生物医学重点实验室;山东中医药大学药学院;山东大学附属千佛山医院口腔科;
【基金】：山东省自然科学基金联合专项(ZR2010HL014)
【分类号】：R318.08
[Abstract]:Objective to study the preparation of white and polysaccharide composite scaffolds for bone tissue engineering regeneration and to optimize the optimum proportion by orthogonal experiment. Methods the purified white and polysaccharide were oxidized and modified by sodium periodate and mixed with hydroxypropyl chitosan and nano-pearl layer powder. The composite scaffolds were prepared by freeze-drying method and the properties of the materials were tested. Results White and polysaccharide composite scaffolds were prepared and the optimal proportion was obtained. the indexes of scaffolds met the requirements of tissue engineering. Conclusion the composite scaffold material of Baihe polysaccharide was successfully optimized by orthogonal analysis, which provided a theoretical basis for its further study and was expected to become a new type of tissue engineering biological scaffold material.
【作者单位】： 山东大学口腔医学院牙周科山东省口腔生物医学重点实验室;山东中医药大学药学院;山东大学附属千佛山医院口腔科;
【基金】：山东省自然科学基金联合专项(ZR2010HL014)
【分类号】：R318.08
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