脑动脉Willis环局部低温的体外模型研究
发布时间：2019-08-05 10:32
【摘要】：目的评价脑动脉低温时Willis环结构对脑组织温度的影响。方法基于患者脑血管CT图像构建脑Willis环体外模型,并通过灌流实验经右侧颈内动脉以30 mL/min的速度注入20℃冷水至中脑动脉,15 min后停止注入,通过27根和1根空间排布的热电偶观察中脑动脉周围区域以及流体的降温及复温特性,并通过注入染色溶液对冷水影响区域进行可视化。结果由右侧颈内动脉进行低温诱导时,冷水溶液主要影响右侧区域,也有少部分通过前脑交通动脉进入前脑动脉;离冷流体所经过的血管越近的区域在较快获得低温的同时,也会有较快的复温速率;由于受多个分叉血管的影响,垂直于中脑动脉流动方向对称区域的温度分布呈非对称性。结论本文首次运用物理模型对脑动脉低温进行验证,为研究血管结构对脑动脉低温的影响以及设计个性化低温治疗方案提供依据。
[Abstract]:Objective to evaluate the effect of Willis ring structure on brain tissue temperature during cerebral artery hypothermia. Methods the in vitro model of cerebral Willis ring was established based on the cerebral vascular CT images of the patients. The right internal carotid artery was injected with cold water at 20 鈩，
本文编号：2523076
[Abstract]:Objective to evaluate the effect of Willis ring structure on brain tissue temperature during cerebral artery hypothermia. Methods the in vitro model of cerebral Willis ring was established based on the cerebral vascular CT images of the patients. The right internal carotid artery was injected with cold water at 20 鈩，
本文编号：2523076
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