胸腺肽α1和乌司他丁对急性颅脑损伤患者的免疫调理作用

发布时间：2017-12-26 21:46

本文关键词：胸腺肽α1和乌司他丁对急性颅脑损伤患者的免疫调理作用　出处：《中国现代医学杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的探讨胸腺肽α1和乌司他丁(UTI)对急性颅脑损伤患者的免疫调理作用。方法将50例急性颅脑损伤患者随机分为对照组和治疗组,对照组予以常规治疗方案;治疗组除常规治疗方案外,同时接受胸腺肽α1及UTI免疫调理治疗。另选取25例健康人作为正常组,并于治疗后1、3、7和14 d取血,检测血清中炎症细胞因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、IL-10、TGF-β_1]和细胞免疫指标[CD4~+、CD8~+、CD4~+/CD8~+、CD14+单核细胞人白细胞DR抗原(HLA-DR)]的水平。结果在治疗3、7和14 d后,对照组和治疗组血液中IL-6、TNF-α、IL-10、TGF-β_1水平升高,CD4~+、CD8~+、CD4~+/CD8~+水平降低,与正常组比较,差异有统计学意义(P0.05);治疗组血液中IL-6、TNF-α水平降低,IL-10、TGF-β_1水平升高;CD4~+、CD8~+和HLA-DR水平升高,与对照组比较,差异有统计学意义(P0.05),同时CD4~+/CD8~+水平也不同程度改善。结论胸腺肽α1和UTI对急性颅脑损伤患者有较好的免疫调理作用。
[Abstract]:Objective to investigate the immunomodulatory effect of thymosin alpha 1 and ulinastatin (UTI) on patients with acute craniocerebral injury. Methods 50 cases of patients with acute craniocerebral injury were randomly divided into control group and treatment group. The control group was given conventional treatment plan, while the treatment group received thymosin 1 and UTI immunomodulatory therapy besides conventional treatment. The other 25 healthy persons were selected as normal group, and in 1, 3, 7 after treatment and 14 d blood serum inflammatory cytokines [interleukin -6 (IL-6), tumor necrosis factor alpha (TNF- alpha), IL-10, _1] and TGF- beta cell immune indexes of [CD4~+, CD8~+, CD4~+/CD8~+, CD14+ monocyte human leukocyte antigen DR (HLA-DR)] level. Results in the treatment of 3, 7 and 14 d, the control group and the treatment group blood IL-6, TNF-, IL-10, alpha TGF- beta _1 level, CD4~+, CD8~+ and CD4~+/CD8~+ were decreased, compared with the normal group, the difference was statistically significant (P0.05); lower IL-6, TNF- levels in the blood increased treatment. IL-10, TGF- beta _1 level; CD4~+, CD8~+ and HLA-DR levels increased, compared with the control group, the difference was statistically significant (P0.05), while CD4~+/CD8~+ levels also improved in different degrees. Conclusion thymosin alpha 1 and UTI have good immunomodulatory effect on patients with acute craniocerebral injury.
【作者单位】：三峡大学仁和医院;三峡大学生物与制药学院;
【基金】：湖北省宜昌市科技计划项目(No:A09301-31)
【分类号】：R651.15
【正文快照】： 颅脑损伤是神经外科最常见的疾病之一,颅脑损伤患者的病情急且危重,变化迅速,致残率及死亡率较高[1]。颅脑创伤后继发的二次脑损伤,是造成脑损害发生、发展的重要原因,其中炎症反应在二次脑损伤(traumatic brain injury,TBI)的病理生理过程中起重要作用。胸腺肽α1是目前较理

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