骨性关节炎软骨和软骨下骨之间信号通路

发布时间：2018-01-02 19:35

本文关键词：骨性关节炎软骨和软骨下骨之间信号通路　出处：《中华骨质疏松和骨矿盐疾病杂志》2016年02期 　论文类型：期刊论文

【摘要】：骨性关节炎(osteoarthritis,OA)的发生和发展离不开软骨和软骨下骨共同病变的过程。信号通路的异常在调控OA软骨下骨和软骨的病变中起重要作用。Wnt、转化生长因子β(transforming growth factorβ,TGFβ)/骨形态发生蛋白(bone morphogenetic protein,BMP)、丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号通路对骨和软骨正常生长发育和代谢有着重要的调控作用,维持了关节的健康和平衡。研究显示,在OA中,这些信号通路的改变不仅可使OA软骨下骨和软骨的细胞表型和分子功能失衡,细胞外基质的合成破坏,软骨下骨骨重塑,还可通过破坏组织细胞的代谢进一步改变骨和软骨的结构及应力承担能力。因此,本文围绕骨关节炎病变中Wnt、TGFβ/BMP、MAPK信号交流在OA中软骨下骨和软骨病变中的作用和机制进行综述,以期为OA和其他骨关节疾病的研究和治疗提供新的方法和思路。
[Abstract]:Osteoarthritis (osteoarthritis, OA) in the occurrence and development process cannot do without bone joint cartilage and subchondral lesions..Wnt plays an important role in the regulation of OA abnormal subchondral bone and cartilage lesions in the signaling pathway, transforming growth factor beta (transforming beta growth factor, TGF) / bone morphogenetic protein (bone morphogenetic protein, BMP), mitogen activated protein kinase (mitogen-activated protein, kinases, MAPK) plays an important role in the regulation of signaling pathway of bone and cartilage of normal growth and metabolism, maintain joint health and balance. The study showed that in OA, the signaling pathway changes not only can make the imbalance of cell phenotype and molecular the function of bone and cartilage OA cartilage extracellular matrix synthesis, destruction, subchondral bone remodeling, but also through the destruction of tissue cell metabolism further changes of bone and cartilage and undertake structural stress Therefore, this article focuses on the role and mechanism of Wnt, TGF beta /BMP and MAPK signal transduction in the subchondral bone and cartilage lesions in OA, in order to provide new methods and ideas for OA and other osteoarthrosis research and treatment.

【作者单位】：华北理工大学附属医院血液科;同济大学附属杨浦医院骨科;
【基金】：国家自然科学基金面上项目(81572218) 上海市自然科学基金(13ZR1439100) 上海市卫生局局级课题面上项目科研基金(20124303)
【分类号】：R684.3
【正文快照】： 骨关节炎(osteoarthritis,OA)是一种以软骨和软骨下骨发生退行性改变为特征的关节疾病[1]。软骨下骨和软骨是关节内应力和生物学作用的主要载体,由于软骨下骨和软骨间有共同的组织细胞起源,两者间可存在共同的信号调节途径。研究显示,Wnt、转化生长因子β(transfor-ming growt

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