闭环自反馈系统持续输注罗库溴铵维持开腹肝癌部分切除术肌松的临床效果

发布时间：2018-01-17 00:35

本文关键词：闭环自反馈系统持续输注罗库溴铵维持开腹肝癌部分切除术肌松的临床效果　出处：《实用癌症杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨闭环自反馈系统持续输注罗库溴铵对维持开腹肝癌部分切除术中肌松的影响。方法临床纳入开腹肝癌部分切除术患者71例,分为研究组与对照组。研究组进行闭环自反馈系统持续输注罗库溴铵,对照组进行罗库溴铵间断静脉注射。观察2组患者术中肌松不良事件发生率、停药后肌松恢复时间、单位时间内麻醉药及罗库溴铵用量以及一般手术情况等。结果研究组术者对肌松不全抱怨率为13.89%,对照组术者对肌松不全抱怨率为37.14%,差异有统计学意义。研究组停药后T1/Tc恢复至基础值25%、75%的时间分别为(25.57±11.09)min、(46.64±14.53)min,对照组分别为(36.38±13.31)min、(58.44±17.98)min,差异均有统计学意义(P0.05);研究组TOF值恢复至75%、90%的时间分别为(57.78±15.82)min、(66.99±15.24)min,对照组分别为(69.02±20.21)min、(78.19±19.65)min,差异均有统计学意义(P0.05)。单位时间内研究组罗库溴铵用量为(12.62±1.69)μg/(kg·min),对照组罗库溴铵用量为(13.45±1.33)μg/(kg·min),差异有统计学意义(P0.05)。2组患者出血量、输液量、输血量等差异无统计学意义(P0.05)。结论闭环自反馈系统持续输注罗库溴铵维持能够为开腹肝癌部分切除术患者提供较好的气管插管条件,缩短术后神经肌肉阻滞自发恢复的时间,还能显著减少术中单位时间内罗库溴铵的用量。
[Abstract]:Objective to investigate the effect of continuous infusion of rocuronium in closed loop self-feedback system on muscle relaxation during partial resection of open liver cancer. Methods 71 cases of partial resection of open liver cancer were included. Two groups were divided into study group and control group. The study group received continuous infusion of rocuronium with closed loop self-feedback system, and the control group received intermittent intravenous injection of rocuronium. The recovery time of muscle relaxation, the dosage of anesthetic and rocuronium per unit time, and the general operation conditions were observed. Results the rate of complaints about muscle loosening was 13.89% in the study group. In the control group, the complaint rate of muscle loosening was 37.14%, the difference was statistically significant. The T _ 1 / T _ c of the study group recovered to a basic value of 25% after the withdrawal of the drug. The time of 75% was 25.57 卤11.09 min, respectively, 46.64 卤14.53 min, and that of control group was 36.38 卤13.31 min. 58.44 卤17.98 min, the difference was statistically significant (P 0.05). The TOF of the study group was 57.78 卤15.82 minutes and 66.99 卤15.24 minutes respectively. The control group was 69.02 卤20.21 min, 78.19 卤19.65 min. The dosage of rocuronium in the study group was 12.62 卤1.69 渭 g / kg 路min. The dosage of rocuronium in the control group was 13.45 卤1.33 渭 g / kg / min, the difference was statistically significant (P 0.05). Conclusion continuous infusion of rocuronium with closed loop self-feedback system can provide better tracheal intubation conditions for partial resection of open liver cancer. The time of spontaneous recovery of neuromuscular block after operation was shortened, and the dosage of necuronium bromide per unit time was significantly reduced.
【作者单位】：湖北文理学院附属医院(
【分类号】：R614;R735.7
【正文快照】： 作者单位:441021湖北文理学院附属医院(湖北省襄阳市中心医院)(The Practical Journal of Cancer,2016,31:1860~1862)罗库溴铵是手术中较为常见的1种非去极化肌松药,由于其主要经肝脏代谢并由胆道排出,因此患者肝功能异常可能导致药效时间的延长[1]。目前研究表明,在肝脏手术

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