介入栓塞治疗中辅助使用右美托咪定对老年颅内动脉瘤患者血流动力学及术后应激的影响

发布时间：2018-01-19 21:08

本文关键词： 右美托咪定颅内动脉瘤介入栓塞血流动力学　出处：《中国老年学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的观察介入栓塞治疗老年颅内动脉瘤辅助使用右美托咪定的临床疗效,分析其对血流动力学及术后应激的影响。方法接受介入栓塞治疗的老年颅内动脉瘤患者使用右美托咪定49例为观察组及不使用50例为对照组。结果观察组丙泊酚(t=6.426,P0.01)及瑞芬太尼(t=2.712,P0.01)使用量均显著低于对照组。两组各指标在麻醉前均无显著差异(P0.05)。观察组平均动脉压(MAP)、颅内压(ICP)及心率(HR)在麻醉满意后、栓塞颅内动脉瘤后、手术结束时均显著低于对照组(P0.05)。两组术后C反应蛋白(CRP)及白细胞介素(IL)-6水平均显著高于术前(P0.05),但观察组术后CRP及IL-6水平均显著低于对照组(P0.05)。结论采用介入栓塞治疗老年颅内动脉瘤中辅助使用右美托咪定有利于维持血流动力学稳定及抑制术后应激水平。
[Abstract]:Objective to observe the clinical effect of interventional embolization in elderly patients with intracranial aneurysms treated with dexmetomidine. Methods 49 elderly patients with intracranial aneurysms treated by interventional embolization were treated with dexmetomidine as observation group and 50 patients as control group. Phenols (. Tl 6.426. P 0.01) and remifentanil 2.712. The usage of P0.01) was significantly lower than that of the control group. There was no significant difference between the two groups before anesthesia. The mean arterial pressure (MAPP) of the observation group was lower than that of the control group (P 0.01). Intracranial pressure (ICP) and heart rate (HRR) after anesthesia were satisfactory, after embolization of intracranial aneurysms. At the end of operation, the levels of C-reactive protein (CRP) and interleukin-6 (IL-6) were significantly lower than those in control group (P 0.05). However, the levels of CRP and IL-6 in the observation group were significantly lower than those in the control group (P 0.05). Conclusion the adjunctive use of dexmetomidine in the treatment of elderly intracranial aneurysms by interventional embolization is helpful to maintain hemodynamic stability and inhibit postoperative stress.
【作者单位】：山东省交通医院神经外科;
【基金】：山东省医药卫生科技项目(No.2009QW015)
【分类号】：R614
【正文快照】： 颅内动脉瘤并非实际意义上的肿瘤,特指发生在颅内动脉血管壁上的异常膨出〔1〕。该病的发病机制并不完全明确,目前认为是颅内血管壁先天性缺陷及管腔内压力过大等多引发〔2,3〕,颅内动脉瘤主要累及老年人群〔4〕。以往常采用开颅手术治疗颅内动脉瘤,但随着微创外科的发展,血管

【相似文献】