氨甲环酸与利伐沙班联合应用对膝关节置换术中减少出血及预防静脉血栓的临床研究

发布时间：2018-01-21 03:34

本文关键词： 氨甲环酸利伐沙班膝关节置换术静脉血栓　出处：《实用药物与临床》2016年03期 　论文类型：期刊论文

【摘要】：目的探讨氨甲环酸与利伐沙班对单侧全膝关节置换后患者减少出血及预防静脉血栓的临床效果。方法随机入选符合条件的行初次单侧全膝关节置换的120例患者随机分为氨甲环酸+利伐沙班组(实验组)与对照组,测量、记录、分析两组患者的失血量和输血量、血红蛋白、红细胞压积、凝血指标、出血事件的发生率及下肢静脉血栓的发生情况。结果实验组的总失血量、隐性出血量、输血量、输血率低于对照组,差异有统计学意义(P0.05);手术后,实验组的血红蛋白(Hb)、红细胞压积(HCT)、膝关节HSS评分均明显优于对照组,差异有统计学意义(P0.05);手术前后,实验组和对照组的纤维蛋白原、凝血酶原时间、活化部分凝血活酶时间比较差异无统计学意义(P0.05);两组患者的临床相关非大出血事件发生率比较差异无统计学意义(P0.05)。结论氨甲环酸与利伐沙班联合应用于初次单侧全膝关节置换术中,可有效减少出血量,同时不影响患者全身的凝血系统,对预防下肢静脉栓塞具有良好的效果,值得在临床推广使用。
[Abstract]:Objective to investigate the clinical effect of trimethocycline and rivastaban on reducing bleeding and preventing venous thrombosis in patients with unilateral total knee arthroplasty. Methods 120 patients with primary total knee arthroplasty were randomly selected. Patients were randomly divided into carbamicylic acid. Livasha team (. Experimental group and control group. The blood loss, hemoglobin, hematocrit, coagulation index, the incidence of bleeding events and the occurrence of lower extremity venous thrombosis were measured, recorded and analyzed in both groups. The amount of recessive blood loss, the amount of blood transfusion and the rate of blood transfusion were lower than those of the control group, and the difference was statistically significant (P 0.05). After operation, the HSS scores of hemoglobin, hematocrit and knee joint in the experimental group were significantly better than those in the control group (P 0.05). Before and after operation, there was no significant difference in fibrinogen, prothrombin time and activated partial thromboplastin time between the experimental group and the control group (P 0.05). There was no significant difference between the two groups in the incidence of non-major hemorrhage events (P 0.05). Conclusion the combination of carbamoic acid and rivastaban is used in the initial unilateral total knee arthroplasty. It can effectively reduce the amount of blood loss and does not affect the coagulation system of the whole body of the patients. It has a good effect on the prevention of venous embolism of the lower extremity and is worth popularizing in clinic.
【作者单位】：河北省廊坊市人民医院骨科;
【基金】：廊坊市科学技术研究与发展计划项目(201401-3130)
【分类号】：R687.4
【正文快照】： 0引言10×109/L;(3)凝血功能正常;(4)术前双下肢静脉彩超未见异常;(5)同意参加本研究,并签署知情近年来,我国老龄化社会进程加快,老龄人口同意书。排除标准:(1)既往明确发生过DVT、PE在全部人口中的比例逐年升高,接受关节置换手或有明显动脉狭窄;(2)术前D-二聚体大于正常高术

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