糖尿病与骨关节炎相关性的Meta分析

发布时间：2018-01-21 07:09

本文关键词： 骨关节炎糖尿病发病机制 Meta分析　出处：《中国矫形外科杂志》2017年11期 　论文类型：期刊论文

【摘要】：[目的]系统评价糖尿病与骨关节炎发病风险的相关性。[方法]计算机检索Pub Med、EMbase、The Cochrane Library、中国知网、维普期刊数据库与万方数据库,搜集糖尿病与骨关节炎发病风险相关性的观察性研究,检索时间均从建库至2016年4月。由2位评价者按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用Rev Man 5.3软件进行Meta分析。[结果]最终纳入文献10篇,共23 143例骨关节炎患者。Meta分析结果显示:糖尿病人群的骨关节炎发病风险是正常人群的1.5倍,其差异具有统计学意义[OR=1.50,95%CI[1.10,2.06,P=0.01],经校正年龄、性别、BMI和体力活动等混杂因素的影响后,糖尿病人群的骨关节炎发病风险是正常人群的1.35倍,其差异具有统计学意义[OR=1.35,95%CI(1.10,1.67,P=0.005]。敏感性分析显示本次研究结果稳健性好。[结论]糖尿病与骨关节炎发病具有相关性,糖尿病可增加骨关节炎的发病风险。
[Abstract]:[Objective] to evaluate the relationship between diabetes mellitus and the risk of osteoarthritis. [Methods] Pub Medbase, the Cochrane Library, Weip Journal Database and Wanfang Database were searched by computer. To collect the correlation between diabetes mellitus and the risk of osteoarthritis, the retrieval time was from the establishment of the database to April 2016. The two evaluators independently screened the literature according to the inclusion and exclusion criteria. After extracting the data and evaluating the methodological quality of the study, Meta analysis was carried out with Rev Man 5.3 software. [Results] A total of 23 143 patients with osteoarthritis were included in 10 articles. The results of Meta analysis showed that the risk of osteoarthritis in diabetic patients was 1.5 times higher than that in normal subjects. The difference is statistically significant. [OR1. 50 and 95 CI. [After adjusting for the influence of age, sex, BMI and physical activity, etc. The risk of osteoarthritis in diabetic patients was 1.35 times higher than that in normal subjects, and the difference was statistically significant. [The sensitivity analysis showed that the results of this study were robust. [Conclusion: diabetes is associated with osteoarthritis, and diabetes can increase the risk of osteoarthritis.
【作者单位】：暨南大学第一临床医学院暨南大学附属第一医院骨关节外科;
【基金】：中国博士后科学基金资助项目(编号:2015M582480) 广东省自然科学基金项目(编号:2016A030313100) 国家自然科学基金项目(编号:81601219)
【分类号】：R587.1;R684.3
【正文快照】： 骨关节炎(osteoarthritis,OA)是中老年人常见的慢性病和多发病,通常累及膝关节等负重关节。病理表现多为软骨退变,软骨下骨硬化,关节边缘骨质增生和骨赘形成,关节囊及其周围韧带的挛缩,最终导致关节畸形和活动障碍,劳动力丧失,甚至生活不能自理,严重影响了老年患者的生活质量[

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