自拟温阳除痹汤联合盐酸氨基葡萄糖治疗阳虚寒凝型KOA疗效观察

发布时间：2018-01-26 21:40

  本文关键词： 温阳除痹汤 盐酸氨基葡萄糖片 膝关节骨性关节炎 Lysholm评分 炎症因子　出处：《重庆医学》2017年18期 　论文类型：期刊论文

【摘要】：目的探讨中药自拟温阳除痹汤联合盐酸氨基葡萄糖治疗阳虚寒凝型膝关节骨性关节炎(KOA)的临床疗效。方法筛选112例郑州大学附属南阳市中心医院收治的KOA且中医证型属于阳虚寒凝型的患者,将其分为观察组(n=57)和对照组(n=55),对照组给予盐酸氨基葡萄糖治疗;观察组在对照组基础上给予自拟温阳除痹汤口服治疗,两组患者连续治疗6周,比较两组临床疗效及药物不良反应情况。结果观察组关节疼痛、晨僵及畏寒肢冷等症状积分及Lysholm评分均低于对照组(P0.05);观察组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)等炎症指标水平均低于对照组(P0.05);观察组患者的总有效率为96.50%%,明显高于对照组的78.18%(P0.05);两组不良反应以胃肠道表现为主,对照组不良反应总发生率为10.91%,观察组为17.54%,两组比较差异无统计学意义(P0.05)。结论中药自拟温阳除痹汤联合盐酸氨基葡萄糖治疗阳虚寒凝型KOA疗效明显,可更好地改善膝关节功能及炎性反应,安全可靠,值得推广。
[Abstract]:Objective to probe into the treatment of knee osteoarthritis caused by yang deficiency and cold coagulation by Chinese herbal medicine Wenyang Debi decoction combined with glucosamine Hydrochloride (Glucosamine Hydrochloride). Methods one hundred and twelve patients with KOA treated in Nanyang Central Hospital affiliated to Zhengzhou University were selected and their TCM syndromes belonged to the type of Yang deficiency and cold coagulation. They were divided into two groups: the observation group (n = 57) and the control group (n = 55). The control group was treated with glucosamine hydrochloride. Observation group on the basis of the control group on the basis of self-prepared Wenyang Zaibi decoction oral treatment, the two groups of consecutive treatment for 6 weeks, compared the two groups of clinical efficacy and adverse drug reactions. Results the observation group joint pain. The scores of morning stiffness and cold limbs and Lysholm scores were lower than those of the control group (P 0.05). The serum levels of TNF- 伪 TNF- 伪 and IL-6 in the observation group were lower than those in the control group (P 0.05). The total effective rate of the patients in the observation group was 96.50, which was significantly higher than that in the control group (78.18). The total incidence of adverse reactions in the control group was 10.91 and that in the observation group was 17.54%. There was no significant difference between the two groups (P 0.05). Conclusion the therapeutic effect of traditional Chinese medicine combined with glucosamine hydrochloride in the treatment of KOA with Yang deficiency and cold coagulation is obvious. Can improve knee joint function and inflammatory reaction better, safe and reliable, worth popularizing.
【作者单位】： 郑州大学附属南阳市中心医院肾病风湿免疫科;郑州大学附属南阳市中心医院骨二科;郑州大学附属南阳市中心医院中医科;南阳理工学院张仲景国医学院;
【分类号】：R684.3
【正文快照】： 膝关节骨性关节炎(knee osteoarthritis,KOA)又称为退行性关节病,是一种以关节疼痛、肿胀为主要临床表现的骨关节疾病,多见于中老年女性。我国发病率为50.00%~80.00%,且随年龄升高发病率呈现逐渐升高趋势[1]。KOA的治疗药物较多,环氧化酶-2(cyclooxygenase-2,COX-2)抑制剂、糖，

本文编号：1466665