右美托咪定注射液对腹腔镜下肾上腺肿瘤切除术老年患者血清超氧化物歧化酶与丙二醛及白细胞介素-6水平影响

发布时间：2018-01-27 14:08

本文关键词： 右美托咪定超氧化物歧化酶丙二醛白细胞介素- 肾上腺肿瘤　出处：《中国临床药理学杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的观察右美托咪定对腹腔镜下肾上腺肿瘤切除术老年患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)以及白细胞介素-6(IL-6)水平的影响。方法将56例进行腹腔镜下肾上腺肿瘤切除术的老年患者随机分为对照组28例和试验组28例。对照组予以临床常规疗法,试验组在与对照组的基础上,在麻醉诱导插管前10 min内,予以右美托咪定注射液0.5μg·kg~(-1),qd,静脉泵注,共7 d。比较2组患者的血清MDA、SOD和IL-6水平,以及比较麻醉前(T1)、气腹后5 min(T_2)、气腹后15 min(T_3)、气腹后30 min(T_4)、气腹结束后5min(T_5)各时点患者心率(HR)、平均动脉压(MAP)变化以及药物不良反应发生率。结果治疗后,试验组和对照组血清中SOD水平分别为(87.64±11.75),(66.70±9.91)U·m L~(-1),MDA水平分别为(6.31±1.52),(8.12±1.61)nmol·m L~(-1),IL-6水平分别为(1.88±0.25),(2.19±0.31)pg·m L~(-1),差异均有统计学意义(P0.05)。在T2、T3时间点,对照组的HR分别为(85.54±12.17),(88.33±12.48)次/分,试验组的HR分别为(79.24±13.47),(80.53±11.38)次/分;对照组的MAP分别为(83.57±11.14),(86.38±11.43)mm Hg,试验组的MAP分别为(79.57±12.44),(80.18±8.33)mm Hg,2组比较差异均有统计学意义(P0.05)。试验组和对照组的药物不良反应均为苏醒期躁动,2组的药物不良反应发生率分别为7.14%(2/28例)和10.71%(3/28例),差异有统计学意义(P0.05)。结论右美托咪定能显著增加血清中SOD水平,降低MDA和IL-6水平,减轻腹腔镜下肾上腺肿瘤切除术患者的应激反应,围术期血流动力学平稳,药物不良反应发生率低。
[Abstract]:Objective to observe the effect of dexmetomidine on serum superoxide dismutase (SOD) in elderly patients undergoing laparoscopic adrenalectomy. Malondialdehyde (MDAA) and interleukin-6 (IL-6). Methods 56 elderly patients undergoing laparoscopic adrenalectomy were randomly divided into control group (n = 28) and experimental group (n = 28). The experimental group was treated with dexmetomidine injection (0.5 渭 g 路kg ~ (-1)) by intravenous infusion 10 min before anesthesia induction and intubation on the basis of the control group. The serum levels of MDA-SOD and IL-6 in the two groups were compared for 7 days, and the levels of MDA-SOD and IL-6 were compared before anesthesia, 5 min after pneumoperitoneum, 5 min after pneumoperitoneum, 15 min after pneumoperitoneum, and 15 min after pneumoperitoneum. 30 min after pneumoperitoneum, 5 min after pneumoperitoneum and 5 min after pneumoperitoneum. Results after treatment, the serum SOD levels in the trial group and the control group were 87.64 卤11.75 respectively. The MDA levels of 66.70 卤9.91 U 路mL ~ (-1) ~ (-1) were 6.31 卤1.52nmol 路mL ~ (-1), respectively (8.12 卤1.61nmol 路m ~ (-1)). The levels of IL-6 were 1.88 卤0.25 and 2.19 卤0.31 PG 路mL ~ (-1), respectively, and the difference was statistically significant (P < 0.05) in T2. At T3 time point, the HR of the control group was 85.54 卤12.17, respectively, 88.33 卤12.48 times per minute, and that of the experimental group was 79.24 卤13.47). 80.53 卤11.38 times / min; The MAP of the control group was 83.57 卤11.14mm Hg, and the MAP of the test group was 79.57 卤12.44). The difference between the two groups was statistically significant (P 0.05). The adverse drug reactions in the test group and the control group were restless during the recovery period. The incidence of adverse drug reactions in the two groups was 7.14 / 28 and 10.71 / 28 respectively). Conclusion dexmetomidine can significantly increase the level of SOD and decrease the levels of MDA and IL-6 in serum. The stress response of patients undergoing laparoscopic adrenalectomy was alleviated, hemodynamics was stable and the incidence of adverse drug reactions was low.
【作者单位】：浙江省台州医院麻醉科;
【基金】：国家医学教育发展中心医学研究基金资助项目(2011-35-02-035)
【分类号】：R614;R736.6
【正文快照】： (浙江省台州医院麻醉科,浙江台州317000)WANG Hui-jun,ZHU Li-jun,HU Guo-qiang(Department of Anesthesia,ZhejiangTaizhou Hospital,Taizhou 317000,Zhejiang Province,China)肾上腺肿瘤是发生在肾上腺皮质、髓质及间质的良、恶性肿瘤以及转移瘤和淋巴瘤,腹腔镜肾上腺肿瘤切

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