氨甲环酸静脉联合局部应用在初次全髋关节置换中疗效及安全性的Meta分析

发布时间：2018-01-28 13:54

本文关键词： 关节成形术置换髋氨甲环酸静脉血栓形成出血组织工程骨科植入物人工假体静脉全髋关节置换出血量血栓形成 Meta分析国家自然科学基金　出处：《中国组织工程研究》2017年03期 　论文类型：期刊论文

【摘要】：背景:在全髋关节置换术中,静脉与局部应用氨甲环酸可显著减少围手术期的失血量和输血率,但目前在临床工作中对氨甲环酸的应用方式仍有争议。目的:应用Cochrane系统方法评价氨甲环酸静脉联合局部用药与单剂量静脉用药在全髋关节置换术中的应用效果及安全性。方法:计算机检索Cochrane Library,Pub Med,Ovid,EMBASE,CBM,万方,VIP,CNKI等数据库,检索时间从建库至2016年7月,检索有关全髋关节置换术中氨甲环酸静脉联合局部与单剂量静脉应用的随机对照试验文献,对2种用药方式的总失血量、术中失血量、术后失血量、输血率、血栓形成、手术时间、住院时间进行Meta分析。结果与结论:(1)共纳入7篇随机对照试验,包含620例患者;(2)Meta分析结果显示,静脉联合局部组在总失血量、术中失血量、术后出血量少、输血率方面较单剂量静脉用药组有明显优势(P0.05),在血栓形成、手术时间、住院时间2组差异无显著性意义(P0.05);(3)结果表明,与单剂量静脉用药相比,在全髋关节置换术中氨甲环酸静脉联合局部应用可明显减少失血量及输血率,但不增加血栓形成率。
[Abstract]:Background: in total hip arthroplasty, intravenous and local application of carbamoic acid can significantly reduce perioperative blood loss and blood transfusion rate. However, there is still controversy about the application of methachloroic acid in clinical work at present. Cochrane system was used to evaluate the efficacy and safety of combined local and single dose intravenous therapy in total hip arthroplasty. The computer retrieves the Cochrane Library. Pub Med#en0# Ovid Ovid EMBASEN CBM, Wanfang VIPN CNKI and other databases, the retrieval time is from the construction of the database to July 2016. To search the literature of randomized controlled trials on the combination of local and single dose veins in total hip arthroplasty, the total blood loss, intraoperative blood loss, postoperative blood loss and blood transfusion rate of the two drugs were studied. Thrombus formation, operation time, and hospitalization time were analyzed by Meta. Results and conclusion: a total of 7 randomized controlled trials, including 620 patients, were included in the study. The results of Meta-analysis showed that the total blood loss, intraoperative blood loss and postoperative blood loss were less in the combined intravenous group, and the blood transfusion rate was significantly higher than that in the single dose intravenous drug group (P0.05). There was no significant difference in thrombus formation, operation time and hospitalization time between the two groups (P 0.05). The results showed that compared with single dose intravenous injection, combined local application of carbamoic acid vein in total hip arthroplasty could significantly reduce blood loss and blood transfusion rate, but did not increase the rate of thrombosis.
【作者单位】：重庆医科大学附属永川医院骨科;
【基金】：国家自然科学基金资助项目(81502329) 重庆医科大学附属永川医院资助项目~~
【分类号】：R687.4
【正文快照】： 0引言Introduction 全髋关节置换已广泛应用于晚期股骨头缺血性坏死、晚期髋关节骨关节炎、风湿性关节炎创伤后股骨头坏死等疾病,其可明显缓解患者疼痛、矫正患者畸形,恢复和改善关节的运动功能,从而提高患者生活质量[1]。然而全髋关节置换因手术创伤大,失血量和输血率高,失

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