肿瘤相关性炎症导致术后认知功能障碍的研究进展

发布时间：2018-01-31 15:00

本文关键词： 炎症术后认知功能障碍肿瘤麻醉　出处：《中国癌症杂志》2017年03期 　论文类型：期刊论文

【摘要】：术后认知功能障碍(postoperative cognitive dysfunction,POCD)是患者在全身麻醉手术后出现的中枢神经系统损害,其危险因素及诱发因素非常复杂,具体机制尚不清楚。近年来,炎症反应在POCD发生、发展中的作用越来越受到重视,且有研究发现肿瘤引起的相关性炎症也起了重要作用。现以围术期炎症反应作为切入点,对其在POCD发生、发展中的作用及围术期麻醉药物及麻醉方法对炎症反应及POCD的影响作一综述,以期深入了解POCD的发生机制,为肿瘤患者中POCD的高危人群麻醉药物和麻醉方法的选择提供理论依据和参考。
[Abstract]:Postoperative cognitive dysfunction. POCD is the central nervous system damage in patients after general anesthesia surgery. Its risk factors and inducing factors are very complex, the specific mechanism is not clear. In recent years, inflammatory reaction occurred in POCD. More and more attention has been paid to the role of development, and some studies have found that tumor-induced inflammation also plays an important role. The role of development and the effect of anesthetic drugs and methods on inflammatory response and POCD during perioperative period were reviewed in order to understand the pathogenesis of POCD. To provide theoretical basis and reference for the selection of anesthetic drugs and anesthetic methods in high risk population of POCD in cancer patients.
【作者单位】：复旦大学附属肿瘤医院麻醉科复旦大学上海医学院肿瘤学系;
【分类号】：R614
【正文快照】： 术后认知功能障碍(postoperative cognitivedysfunction,POCD)是指患者在手术或麻醉后出现精神错乱、焦虑、人格改变及记忆受损等,常见于接受胸科手术、重大手术、急症手术后的老年患者,在中青年患者中的发病也时有报道[1]。一项国外多中心调查显示,1 218例年龄大于60岁的老年

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