AQP4与创伤性脑水肿的研究进展

发布时间：2018-02-02 22:17

本文关键词： 颅脑创伤脑水肿水通道蛋白炎症因子　出处：《国际神经病学神经外科学杂志》2017年02期 　论文类型：期刊论文

【摘要】：创伤性脑损伤(traumatic brain injury,TBI)后的脑水肿是其最常见且最重要的病理生理反应,可引起颅内压增高,甚至导致脑组织移位和脑疝,是临床上患者死亡和重度残疾的主要原因。消除脑水肿成为治疗TBI的关键靶点,直接关系到颅脑创伤患者的预后。水通道蛋白4(Aquaporin-4,AQP4)是哺乳动物脑组织中含量最丰富的水通道蛋白,对维持脑组织内的水平衡具有重要作用。近几年随着研究的不断深入,越来越多的研究认为AQP4在颅脑创伤后脑水肿的形成过程中扮演重要角色,其表达和定位与颅脑创伤早晚期的脑水肿的类型有关。本文就AQP4与创伤性脑水肿关系的相关研究进展进行综述。
[Abstract]:Brain edema after traumatic brain injuryis the most common and important pathophysiological response, which can lead to increased intracranial pressure, even brain tissue displacement and brain hernia. It is the main cause of death and severe disability in clinical patients. The elimination of brain edema has become a key target in the treatment of TBI and is directly related to the prognosis of patients with craniocerebral trauma. Aquaporin-4aquaporin-4AQP4 is the most abundant aquaporin-4 aquaporin-4AQP4 in mammalian brain. It plays an important role in maintaining water balance in brain tissue. In recent years, with the continuous development of research, more and more studies believe that AQP4 plays an important role in the formation of brain edema after traumatic brain injury. Its expression and localization are related to the type of brain edema in the early and late stage of traumatic brain injury. This article reviews the relationship between AQP4 and traumatic brain edema.
【作者单位】：南昌大学第一附属医院神经外科;中国人民解放军第一七一医院神经内科;
【基金】：国家自然科学基金(81360188) 江西省科技计划项目(00041081120919028)
【分类号】：R651.15
【正文快照】： 创伤性脑损伤(traumatic brain injury,TBI)是青少年和及成年人死亡和残疾的最常见原因。[1]据报道,发达国家每年TBI发生率约为150~250/10万,而我国约为100~200/10万。[2]我国颅脑创伤数据库相关资料的分析结果显示重型TBI患者死亡率为27.23%,不良预后率(预后不良是指患者死亡

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