胸腰椎后路内固定术后早期手术部位感染患者的促炎因子和抗炎因子水平变化研究

发布时间：2018-02-03 11:30

本文关键词： 胸腰椎后路内固定术手术部位感染促炎因子抗炎因子　出处：《中华医院感染学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨胸腰椎后路内固定术后早期手术部位感染对患者促炎因子和抗炎因子水平的影响,为手术部位感染预防和相关研究提供临床借鉴和参考。方法选取医院2013年1月-2014年12月临床收治的胸腰椎后路内固定术患者154例,根据早期手术部位感染情况将患者分为感染组和非感染组,各77例;针对两组患者的IgA、IgE、IgGl、IgG2、IgG等各项免疫指标和IL-1、IL-6、IL-8、TNF-α等各项血清促炎因子以及IL-4、IL-10、IL-13、TGF-β等各项血清抗炎因子进行观察和比较。结果感染组IgA、IgE、IgGl、IgG2、IgG低于非感染组;感染组IL-1、IL-6、IL-8、TNF-α高于非感染组;感染组IL-4、IL-10、IL-13、TGF-β高于非感染组,差异均有统计学意义(P0.05)。结论胸腰椎后路内固定术后早期手术部位感染可导致患者免疫指标降低、促炎因子和抗炎因子水平显著升高,针对上述指标的检测对于感染的监控具有重要的意义。
[Abstract]:Objective to investigate the posterior internal fixation and early postoperative surgical site infection for patients with proinflammatory and anti-inflammatory cytokines level of the thoracic and lumbar spine, for the prevention of surgical site infection and related research to provide clinical reference. 154 cases of internal fixation methods in clinical hospital in January 2013 December -2014 years after thoracolumbar vertebral, according to early surgical site infection the patients were divided into infection group and non infection group, 77 cases in each; the two groups of patients with IgA, IgE, IgGl, IgG2, IgG and other immune indexes and IL-1, IL-6, IL-8, TNF- alpha and other proinflammatory cytokines and serum IL-4, IL-10, IL-13, TGF- were observed and compared the beta results the infection group. Serum anti inflammatory factor IgA, IgE, IgGl, IgG2, IgG lower than the non infection group; IL-1 infection group, IL-6, IL-8, TNF- were higher than those in non infection group; IL-4 infection group, IL-10, IL-13, TGF- beta is higher than the non infected group, the differences were statistically significant (P0.0 5). Conclusion thoracolumbar posterior internal fixation and early postoperative surgical site infection can lead to decreased immune index of patients, proinflammatory and anti-inflammatory cytokines were significantly increased, the detection index is of great significance for infection control.

【作者单位】：南阳医学高等专科学校第一附属医院麻醉科手术部;南阳医学高等专科学校影像实验室;南阳医学高等专科学校第一附属医院护理部;南阳医学高等专科学校第一附属医院骨科;
【基金】：河南省教育厅科学技术研究重点项目(141302111239)
【分类号】：R687.3
【正文快照】： 随着临床医学的不断发展以及相关医疗器械水平的不断提高,脊柱内固定治疗方法的临床应用得到了广泛的推广,其临床治疗的综合效果也得到了广大医师和患者的推崇[1]。采用后路固定融合技术,可以对胸腰椎的相关疾病进行有效治疗,临床比较优势明显,患者临床的矫正效果更好,术后的

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