肌少症与代谢危险因素的相关性研究

发布时间：2018-02-04 20:45

本文关键词： 肌少症肥胖代谢危险因素　出处：《医学研究生学报》2017年02期 　论文类型：期刊论文

【摘要】：目的肌少症和代谢综合征的发生发展具有相似的病理生理机制。文中旨在观察健康体检人群中肌少症的发生率及其与血压、血糖、血脂和血尿酸水平等代谢危险因素之间相关。方法收集2011年3月至6月间在南京军区南京总医院体检中心1191例健康体检者的体检资料,采用人体成分分析仪分析体重、骨骼肌、体脂肪、体重指数、腰围、体脂百分数、腰臀比、内脏脂肪面积等数据,观察肌少症的发生情况,同时测定三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDL-C)、尿酸和空腹血糖等。结果本组观察对象肌少症检出率为5.21%,其中60岁以上人群中肌少症检出率最高(11.11%);超重和肥胖的检出率分别为33.8%和10.2%。随着BMI增加,肌少症的检出率呈增加趋势,超重和肥胖者中肌少症的检出率分别为5.47%和26.23%;与正常受检者相比,肌少症患者体重[(66.34±11.75)kg vs(76.71±12.84)kg]、BMI[(23.37±3.13)kg/cm2vs(28.05±3.66)kg/cm2]、体脂百分比[(25.33±6.06)%vs(36.76±4.47)%]、腰围[(83.19±9.56)cm vs(95.45±13.74)cm]和内脏脂肪面积[(88.96±29.74)cm2vs(136.91±25.56)cm2]均明显升高,差异有统计学意义(P0.05)。临床生化结果显示与正常受检者相比,肌少症患者收缩压[(125.59±30.04)mm Hg vs(139.39±19.79)mmHg]、舒张压[(75.82±11.95)mm Hg vs(82.34±10.96)mm Hg]、TG[(1.98±1.72)mmol/L vs(1.56±1.12)mmol/L]及尿酸[(335.55±96.07)mmol/L vs(313.75±83.07)mmol/L]也明显升高,差异有统计学意义(P0.05)。与正常受检者相比,肌少症、肥胖以及肌少症合并肥胖患者舒张压、空腹血糖、尿酸、低密度脂蛋白胆固醇水平异常的检出率逐步升高(P0.05);校正性别和年龄等混杂因素进行logistic回归分析,肌少症、肥胖及肌少症合并肥胖患者出现收缩压、舒张压、尿酸、低密度脂蛋白胆固醇异常的比值比逐渐升高。结论肌少症可能与代谢危险因素的发生有关。因此,尽早发现骨骼肌质量减少有助于识别代谢综合征的易患人群,对防治慢性病具有重要意义。
[Abstract]:Objective the occurrence and development of hypomuscular syndrome and metabolic syndrome have similar pathophysiological mechanisms. The purpose of this paper is to observe the incidence of hypomyopathy and its relationship with blood pressure and blood glucose in healthy people. Methods from March 2011 to June, 1 191 healthy persons were collected from Nanjing General Hospital of Nanjing military region. The body weight, skeletal muscle, body fat, body mass index, waist circumference, percentage of body fat, waist-hip ratio and visceral fat area were analyzed by body composition analyzer. At the same time, the levels of triglyceride (TGG), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDL-C) were determined. Results the detection rate of hypomyopathy was 5.21, and the highest rate of hypomyosis was 11.11% among the people over 60 years old. The prevalence rates of overweight and obesity were 33.8% and 10.2, respectively. With the increase of BMI, the detection rate of hypomyopathy showed an increasing trend. The detection rates of hypomuscular disease in overweight and obese patients were 5.47% and 26.23 respectively. Compared with the normal subjects, the weight of the patients with hypomuscular disease was higher than that of the normal subjects. [66.34 卤11.75kg. vs(76.71 卤12.84kg. [23.37 卤3.13 kg / cm ~ 2 / cm ~ 2 vs 28.05 卤3.66 kg / cm ~ 2], percentage of body fat. [25.33 卤6.06% vs 36.76 卤4.47%, waist circumference. [83.19 卤9.56cm. vs(95.45 卤13.74cm. and visceral fat area. [88.96 卤29.74 cm ~ (2) vs ~ (2) (136.91 卤25.56) cm ~ (2) increased significantly. The difference was statistically significant (P 0.05). The clinical biochemical results showed that compared with the normal subjects, the systolic blood pressure of the patients with hypomyopathy was higher than that of the normal subjects. [125.59 卤30.04 mm Hg vs(139.39 卤19.79 mm Hg, diastolic blood pressure. [75.82 卤11.95 mm Hg vs(82.34 卤10.96 mm Hg] TG. [1.98 卤1.72 mmol / L vs(1.56 卤1.12 mmol / L] and uric acid. [335.55 卤96.07 mmol / L vs(313.75 卤83.07 mmol / L also increased significantly. Compared with normal subjects, diastolic blood pressure (DBP), fasting blood glucose (FBG) and uric acid (uric acid) in patients with hypomuscular disease, obesity and hypomyopathy complicated with obesity were significantly different (P 0.05). The detection rate of abnormal low density lipoprotein cholesterol (LDL-C) was gradually increased (P 0.05). Adjusted for gender and age and other confounding factors for logistic regression analysis, hypomuscular disease, obesity and obesity with obesity patients with systolic blood pressure, diastolic blood pressure, uric acid. Conclusion hypomyopia may be associated with metabolic risk factors. Therefore, early detection of skeletal muscle mass reduction is helpful to identify the susceptible population with metabolic syndrome. It is of great significance to prevent and cure chronic diseases.
【作者单位】：南京军区南京总医院营养科;
【分类号】：R589;R685
【正文快照】： 0引言近年来,随着人口老龄化进程的加快,多种增龄性疾病已引起人们的广泛关注。世界卫生组织估计,2050年全球65岁以上老年人口数至少达到20亿[1]。老龄化过程会带来一系列体成分的改变,如骨骼肌含量减少。肌少症就是一种与肌肉、代谢及认知功能损害有关的老年综合征,表现为与

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