氟比洛芬酯对骨科手术超前镇痛及术后镇痛的临床疗效评价

发布时间：2018-02-14 07:08

本文关键词： 氟比洛芬酯骨科手术镇痛 C反应蛋白前列腺素E　出处：《中国临床药理学杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的观察氟比洛芬酯注射液对骨科手术超前镇痛及术后镇痛的临床疗效。方法 78例骨科手术治疗的患者随机分为试验组39例和对照组39例。对照组患者麻醉前15 min静脉注射帕瑞昔布钠20 mg(10 m L);使用丙泊酚1~2mg·kg~(-1)诱导麻醉,术中使用异氟烷维持麻醉;术后将帕瑞昔布钠60 mg加0.9%氯化钠配至100 m L,静脉滴注。试验组患者麻醉前15 min静脉注射氟比洛芬酯50 mg;使用丙泊酚1~2 mg·kg~(-1)诱导麻醉,术中使用异氟烷维持麻醉;术后将氟比洛芬酯50 mg加0.9%氯化钠配至100 m L,静脉滴注。记录患者术前或术后的平均动脉压、心率、视觉模拟评分(VAS)、Ramsay镇静评分(RSS)以及前列腺素E2(PGE2)、血清C反应蛋白(CRP)含量;同时统计2组的不良反应发生率。结果除术后即刻的VAS评分试验组低于对照组外(P0.05),2组患者的平均动脉压和心率、VAS、RSS差异均无统计学意义。试验组术后24 h的血清CRP含量为(16.77±5.52)mg·L~(-1),显著低于对照组的(20.68±7.76)mg·L~(-1)(P0.05);试验组术后24 h的血清PGE2含量与对照组差异无统计学意义(135.1 vs 141.6 pg·mL~(-1),P0.05)。试验组的不良反应发生率显著低于对照组(7.7%vs 20.5%,P0.05)。结论氟比洛芬酯注射液用于骨科手术患者镇痛效果较好,减轻患者的应激反应,减少不良反应发生率。
[Abstract]:Objective to observe the clinical effect of flurbiprofen injection on preemptive analgesia and postoperative analgesia in orthopedic surgery. Methods 78 patients undergoing orthopedic surgery were randomly divided into trial group (n = 39) and control group (n = 39). Anesthesia was induced by intravenous injection of paroxib sodium for 15 min (20 mg(10 mL) and propofol (2 mg 路kg ~ (-1)). Intraoperative anesthesia was maintained with isoflurane, 60 mg paroxib sodium plus 0.9% sodium chloride was injected intravenously to 100ml after operation. In the trial group, 50 mg flurbiprofen ester was injected intravenously 15 min before anesthesia, and 2 mg 路kg -1 propofol was used to induce anesthesia. Intraoperative maintenance anesthesia was performed with isoflurane, 50 mg flurbiprofen ester plus 0.9% sodium chloride was injected intravenously after operation. Mean arterial pressure and heart rate were recorded before and after operation. Visual analogue score (VAS) and Ramsay sedative score (RSSs) and prostaglandin E _ 2 (PGE _ 2), serum C-reactive protein (CRP) levels; Results there was no significant difference in the mean arterial pressure and heart rate of VAS between the two groups except that in the control group (P 0.05). The serum CRP in the trial group 24 hours after operation was not significantly different from that in the control group. The level of serum PGE2 in the trial group was significantly lower than that in the control group (16.77 卤5.52 mg 路L ~ (-1)), which was significantly lower than that in the control group (20.68 卤7.76) mg 路L ~ (-1) (P ~ (0.05)), but there was no significant difference between the two groups at 24 hours after operation, and there was no significant difference between the experimental group and the control group (135.1 vs 141.6 PG 路mL ~ (-1) P 0.055.The incidence of adverse reactions in the trial group was significantly lower than that in the control group (7.7g / L vs 20.5p 0.05). Conclusion flurbiprofen ester is injected with flurbiprofen ester. The analgesic effect of injecting liquid in orthopedic surgery patients is better. Reduce the stress reaction and the incidence of adverse reactions.
【作者单位】：瑞安市人民医院护理部;
【分类号】：R614

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