羟基磷灰石梯度涂层复合重组人骨形态发生蛋白-2股骨柄与SL-PLUS MIA股骨柄对全髋关节置换术后患者骨密度的影响

发布时间：2018-02-20 15:06

本文关键词： 关节成形术置换髋骨形态发生蛋白质羟基磷灰石类　出处：《中国全科医学》2017年S1期 　论文类型：期刊论文

【摘要】：目的研究分析羟基磷灰石(HA)梯度涂层复合重组人骨形态发生蛋白-2(BMP)股骨柄与SLPLUS MIA股骨柄对全髋关节置换术(THA)后患者骨密度(BMD)的影响。方法选取2015年2月—2016年2月期间在息县人民医院行THA的60例患者(60髋)为研究对象,按照随机单盲法分为观察组(n=30)和对照组(n=30),对照组患者采用SL-PLUS MIA股骨柄,观察组采用HA梯度涂层复合BMP股骨柄,观察髋关节活动度、BMD、并发症发生率、Harris评分标准变化情况。结果术后12个月两组患者髋关节活动度和Harris评分高于术前(P0.05);观察组患者术后各时间点BMD比较,差异无统计学意义(P0.05),对照组术后6、12个月1、2、6、7区BMD低于术后1个月(P0.05);观察组患者假体松动发生率低于对照组(P0.05)。结论 HA梯度涂层复合BMP股骨柄与SL-PLUS MIA股骨柄行THA均具有不错的疗效,有利于改善髋关节功能,提高髋关节活动度,但HA梯度涂层复合BMP股骨柄术后骨量丢失少,假体松动发生风险小,安全性更高。
[Abstract]:Objective to study the effect of hydroxyapatite (HA) gradient coating combined with recombinant human bone morphogenetic protein (BMP) and SLPLUS MIA femur pedicle on bone density (BMD) after total hip arthroplasty (THR). Methods from February 2015 to February 2016, the bone mineral density (BMD) of patients undergoing total hip arthroplasty was studied. During this period, 60 patients (60 hips) who were treated with THA in Xixian people's Hospital were studied. According to the random single blind method, the patients in the observation group were divided into two groups: the observation group (n = 30) and the control group (n = 30). The patients in the control group were treated with SL-PLUS MIA femur petiole, and the patients in the observation group were treated with HA gradient coating combined with BMP. Results the hip motion and Harris scores of the two groups were higher than those of the patients before operation (P 0.05), the BMD of the patients in the observation group were compared at each time point after operation. There was no significant difference (P 0.05). The BMD in the control group was lower than that in the control group at 1 month and 12 months after operation, and the incidence of prosthesis loosening in the observation group was lower than that in the control group (P 0.05). Conclusion HA gradient coating combined with BMP femur petiole and SL-PLUS MIA femur stalk have good effect on THA. It can improve hip function and improve hip motion, but HA gradient coating combined with BMP has less loss of bone mass, less risk of prosthesis loosening and higher safety.
【作者单位】：河南省信阳市息县人民医院;武汉大学人民医院;
【分类号】：R687.4

【相似文献】