神经节苷脂注射液治疗重症颅脑损伤患者的临床研究

发布时间：2018-02-26 12:48

本文关键词： 急性颅脑损伤神经节苷脂注射液神经元特异性烯醇化酶蛋白酶联免疫吸附法　出处：《中国临床药理学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的观察神经节苷脂(Gg)注射液对重症颅脑损伤患者血清神经元特异性烯醇化酶(NSE)及S100B蛋白浓度的影响。方法 68例急性颅脑损伤患者随机分为对照组34例和试验组34例。对照组给予复方甘露醇注射液,每次200m L,每天2次,静脉滴注;脑复康1.2 g,每天3次,口服;试验组在对照组的基础上静脉滴注单唾液酸四己糖神经节苷脂100 mg,每天1次,2组疗程均为2个月。分别在患者住院后的第8,24,48,72,120 h采集空腹外周静脉血,用酶联免疫吸附法对2组患者血清NES和S100B蛋白进行检测,同时评价2组患者的临床疗效,观察2组的药物不良反应发生情况。结果治疗后120 h,试验组和对照组的血清NSE分别为(13.21±2.78),(18.52±3.45)ng·mL~(-1),S100B分别为(2.08±0.85),(3.76±2.14)ng·mL~(-1),差异有统计学意义(P0.05)。试验组有效率为82.35%(28/34例),对照组为58.82%(20/34例),差异有统计学意义(P0.05)。治疗后2,4周,试验组的简易精神状态检查量表(MMSE)评分分别为(23.44±3.15),(27.41±3.48)分,对照组的MMSE分别为(20.35±2.35),(22.24±2.97)分,差异有统计学意义(P0.01)。2组治疗过程中均没有出现明显的药物不良反应。结论神经节苷脂注射液可以有效降低重症颅脑损伤患者的血清NSE和S100B蛋白浓度。
[Abstract]:Objective to observe the effect of ganglioside Gg injection on serum neuron-specific enolase (NSE) and S100B protein concentration in patients with severe craniocerebral injury. Methods Sixty-eight patients with acute craniocerebral injury were randomly divided into control group (n = 34) and experimental group (n = 34). The control group was treated with compound mannitol injection. Each time 200 mL, twice daily, intravenous drip, Naofukang 1.2 g, 3 times a day, oral; The experimental group received 100 mg monosialic tetrahexose ganglioside intravenously on the basis of the control group, and the course of treatment of the two groups was 2 months once a day. Serum NES and S100B protein were detected by enzyme-linked immunosorbent assay (Elisa). Results at 120 hours after treatment, the serum NSE of the test group and the control group were 18.52 卤3.45 ng 路mL ~ (-1), respectively (2.08 卤0.85) ng 路mL ~ (-1), respectively (2.08 卤0.85) ng 路mL ~ (-1), and the difference was statistically significant (P = 0.05). The effective rate of the trial group was 82.35% 28 / 34, and the control group was 58.822 / 2034 cases. There was statistical significance (P 0.05). 2 weeks after treatment, 4 weeks after treatment, The scores of MMSE in the test group were 23.44 卤3.15 and 27.41 卤3.48, respectively, and the MMSE in the control group were 20.35 卤2.35 and 22.24 卤2.97, respectively. Conclusion ganglioside injection can effectively reduce the concentration of serum NSE and S100B protein in patients with severe craniocerebral injury.
【作者单位】：海南省人民医院神经科;
【基金】：国家自然科学基金资助项目(81260043) 海南省医学科研重点基金资助项目(2012ZD-06)
【分类号】：R651.15

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