411例膝关节骨性关节炎患者的流行病学调查分析

发布时间：2018-02-28 15:31

本文关键词： 膝关节骨性关节炎流行病学　出处：《山东中医药大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:通过调查研究411例膝关节骨性关节炎患者的临床资料,对其致病因素、发病特点、变化规律等资料进行系统统计分析,了解膝关节骨性关节炎的流行病学特点,探究膝关节骨性关节炎的发生发展规律,指导对膝关节骨性关节炎的临床诊疗工作。方法:自2013年01月01日至2014年12月31日,山东中医药大学附属医院关节骨科收治膝关节骨性关节炎患者总计472例,其中符合本课题纳入标准的411例,采用病例资料统计配合电话回访的方式统计所有这些患者的临床资料,包括性别、职业、出入院时间、入院年龄、发病年龄、体重指数、患膝内外翻畸形有无等相关数据进行统计整理,并应用统计学方法进行系统归纳分析,主要包括独立样本t检验和单样本t检验,以P值等于0.05作为判断统计结果具有显著性差异的标准。成果:411例患者均获得完整的临床资料,其中男性患者87人,占27.97%,女性患者324人,占78.83%,男女比例1:3.72,平均年龄65.2±8.1岁,平均发病年龄55.6±10.8岁。对其进行的独立样本t检验表明,男女患者的年龄分布有显著性差异(P0.05),女性患者的发病年龄要明显早于男性患者。在体重指数方面的统计结果分析显示,与体重指数=23这一超重临界值相比,411例患者有明显的超重倾向(P0.05),然而,男女患者在体重指数方面的对比并无明显不同。绝大多数患者存在不同程度的膝关节内外翻畸形,其中以内翻畸形最为常见,外翻畸形少见,也有极少部分患者并没有膝关节内外翻畸形。对于患者发病部位的统计分析结果显示,双膝发病的患者207人,占患者总人数的50.36%,单膝发病的患者204人,占患者总人数的49.64%,其中左右膝发病率基本持平,其差异无统计学意义。患者的职业分布及城乡分布情况经统计学分析无明显统计学差异。相比较与2012年同一时期,2013年收治的膝关节骨性关节炎患者的数量所占比例有明显增高。结论:年龄、性别、体重指数对膝关节骨性关节炎的发病有一定程度的影响。膝关节骨性关节炎一般好发于40~70岁的患者,在50~60岁的人群中,膝关节骨性关节炎的发病率最高;肥胖是膝关节骨性关节炎发病的诱导因素之一,体重指数较高的人有更高的几率患膝关节骨性关节炎。膝关节骨性关节炎可以引起患者的膝关节内外翻畸形,一般来说,膝关节骨性关节炎更容易引起膝关节内翻畸形,较少导致膝关节外翻畸形。职业及城乡分布与膝关节骨性关节炎的发病并没有显著关系,城乡居民的膝关节骨性关节炎发病几率基本相同。随着时间的发展,膝关节骨性关节炎的发病率有增多的趋势,应当引起医务人员和好发人群更多的关注。
[Abstract]:Objective: to investigate the clinical data of 411 patients with knee osteoarthritis, and to analyze systematically the pathogenic factors, the characteristics of the disease and the changes of the disease, so as to understand the epidemiological characteristics of the osteoarthritis of the knee. To explore the occurrence and development of knee osteoarthritis and to guide the clinical diagnosis and treatment of knee osteoarthritis. Methods: from January 1st 2013 to December 31st 2014, A total of 472 patients with knee osteoarthritis were admitted to the Department of Orthopaedics of the affiliated Hospital of Shandong University of traditional Chinese Medicine. The clinical data of all these patients, including sex, occupation, time out of hospital, admission age, age of onset, body mass index, were analyzed by using case statistics and telephone return visits. The related data such as the existence or absence of varus genicularis were statistically analyzed, and the statistical methods were used to analyze them systematically, including independent t-test and single-sample t-test. Results the clinical data of 411 patients were obtained, including 87 male patients (27.97%) and 324 female patients (78.833%). The ratio of male to female was 1: 3.72, with an average age of 65.2 卤8.1 years. The average age of onset was 55.6 卤10.8 years old. T test of independent sample showed that there was a significant difference in age distribution between male and female patients (P 0.05). The age of onset in female patients was significantly earlier than that in male patients. The statistical results of body mass index showed that the age distribution of female patients was significantly earlier than that of male patients. Compared with the critical value of body mass index (BMI) of 23, 411 patients had significant tendency to be overweight, however, there was no significant difference in body mass index between male and female patients. Most of the patients had different degrees of knee joint varus deformity. Varus deformities are the most common, valgus deformities are rare, and few patients do not have varus deformities of the knee. Accounting for 50.36% of the total number of patients, 204 patients with single knee disease, accounting for 49.64% of the total number of patients, the incidence of left and right knees was basically equal. There was no statistical difference between them. There was no statistical difference in the occupational distribution and urban and rural distribution of the patients. Compared with the same period on 2012, the proportion of patients with osteoarthritis of knee joint treated in 2013 was higher than that in the same period on 2012. There was a marked increase in the number of cases. Conclusion: age, Sex and body mass index (BMI) had a certain influence on the incidence of knee osteoarthritis. The incidence of knee osteoarthritis was the highest in the population of 50 to 60 years old. Obesity is one of the leading factors in the development of knee osteoarthritis, and people with higher BMI are more likely to develop osteoarthritis of the knee. Knee osteoarthritis is more likely to cause varus deformity of the knee joint and less to the valgus of knee joint. There is no significant relationship between occupation and urban and rural distribution of knee joint osteoarthritis. The incidence rate of knee osteoarthritis in urban and rural residents is basically the same. With the development of time, the incidence of knee osteoarthritis has an increasing trend, which should be paid more attention to by medical staff and people who are prone to knee joint osteoarthritis.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R684.3

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