小剂量醒脑静注射液在中重型颅脑损伤患者治疗中的作用评价

发布时间：2018-03-01 14:34

本文关键词： 小剂量醒脑静注射液中重型颅脑损伤作用评价　出处：《重庆理工大学》2016年硕士论文　论文类型：学位论文

【摘要】：颅脑损伤(TBI)是平战结合的一种常见病。在中国,每年约有60万人死亡,约有10万人死亡,造成直接经济损失超过10亿元人民币。脑损伤的发生率最高,死亡率为第一,它已成为一个严重的社会危害。颅脑损伤的死亡率仍然很高,在神经外科中对其治疗方法的研究仍然是研究的重点。但很少有重视早期干预的大脑损伤。目的:通过对在中重型颅脑损伤患者治疗中使用小剂量醒脑静注射液后的效果进行评价,来寻求对该类型患者有效的治疗方法,以减少费用,改善预后,降低死亡率。方法:采用单盲随机对照试验设计。通过对重庆市江津区中心医院神经外科从2012年5月至2014年4月收治的中重型颅脑损伤患者,共120例进行研究。将患者随机分为60例治疗组和60例对照组。治疗组在常规治疗基础上加用醒脑静注射液10ml静滴,每日一次;对照组给予常规治疗。通过对患者GCS评分、手术患者颅内压测值、并发症的发生(肺部感染、消化道出血、癫痫)进行观察、比较。本研究中各种计数资料采用X2检验,对计量资料采用t检验。结果:治疗组在提高GCS评分、降低颅内压、降低肺部感染发生率、消化道出血发生率等方面优于对照组(P0.05)。在降低癫痫发生率方面,与对照组无显著差异(P0.05)。结论:在中重型颅脑损伤患者的治疗中,通过使用小剂量醒脑静注射液(10ml),能够达到提高GCS评分、降低颅内压、降低肺部感染和消化道出血发生率的作用。由此可降低治疗费用,改善预后,降低死亡率。
[Abstract]:Brain injury (TBI) is a common disease combined with peacetime and war. In China, about 600,000 people die each year and 100,000 die, causing direct economic losses of more than 1 billion yuan. The incidence of brain injury is the highest, and the death rate is the first. It has become a serious social hazard. The mortality rate of brain injury is still very high. The research on the treatment of neurosurgery is still the focus of the research. However, little attention has been paid to the early intervention of brain injury. Objective: to use small dose Xingnaojing injection in the treatment of patients with moderate and severe craniocerebral injury. After the evaluation of the effect, To find an effective treatment for this type of patient to reduce costs and improve prognosis. Methods: a single blind randomized controlled trial was used to treat the patients with moderate and severe craniocerebral injury in the neurosurgery department of the Central Hospital of Jiang Jin District of Chongqing from May 2012 to April 2014. 120 patients were randomly divided into treatment group (n = 60) and control group (n = 60). The treatment group received 10 ml Xingnaojing injection once a day on the basis of routine treatment, and the control group was given routine treatment. Intracranial pressure (ICP), complications (pulmonary infection, gastrointestinal hemorrhage, epilepsy) were observed and compared. Results: the treatment group was superior to the control group in improving GCS score, reducing intracranial pressure, reducing the incidence of pulmonary infection, and the incidence of gastrointestinal hemorrhage. Conclusion: in the treatment of patients with moderate and severe craniocerebral injury, low dose Xingnaojing injection 10 ml can improve GCS score and reduce intracranial pressure. The effect of reducing the incidence of pulmonary infection and gastrointestinal hemorrhage can reduce the cost of treatment, improve prognosis and reduce mortality.
【学位授予单位】：重庆理工大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R651.15

【引证文献】