独活寄生丸联合塞来昔布对老年膝骨关节炎患者炎性因子、内皮功能及膝关节功能的影响

发布时间：2018-03-02 04:23

  本文关键词： 独活寄生丸 塞来昔布 膝骨性关节炎 炎性因子 内皮功能 膝关节功能　出处：《中国老年学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨独活寄生丸联合塞来昔布对老年膝骨关节炎(KOA)患者炎性因子、内皮功能及膝关节功能的影响。方法选择老年KOA患者98例,按照随机数字表法分为观察组与对照组各49例。对照组给予塞来昔布治疗,观察组在对照组基础上结合独活寄生丸治疗。两组疗程均为6 w。比较两组疗效,治疗前后关节压痛指数和静息痛指数、血清炎症因子、内皮功能及膝关节功能改善情况。结果观察组治疗总有效率高于对照组,治疗后关节压痛指数和静息痛指数评分低于对照组,白细胞介素(IL)-1、IL-6、IL-8水平低于对照组一氧化氮(NO)水平高于对照组,而内皮素(ET)-1水平低于对照组,Lysholm膝关节评分高于对照组(均P0.05)。结论独活寄生丸联合塞来昔布对老年KOA患者疗效明显,且降低炎性因子IL-1、IL-6、IL-8水平,改善内皮功能及膝关节功能,具有重要研究意义。
[Abstract]:Objective to investigate the effects of Duhuzheng pills combined with celecoxib on inflammatory factors, endothelial function and knee joint function in elderly patients with osteoarthritis of knee. Methods 98 elderly patients with KOA were selected. According to the method of random number table, 49 cases in the observation group and 49 cases in the control group were divided into two groups. The control group was treated with celecoxib, and the observation group was treated with Duhuozhongwan on the basis of the control group. The course of treatment was 6 ws. the curative effect was compared between the two groups. Before and after treatment, the joint tenderness index, resting pain index, serum inflammatory factor, endothelial function and knee joint function were improved. Results the total effective rate in the observation group was higher than that in the control group. After treatment, the scores of joint tenderness index and resting pain index were lower than those of the control group, and the level of IL-8 was lower than that of the control group, and the level of IL-8 was higher than that of the control group. However, the level of endothelin (et) was lower than that of control group (P < 0.05). Conclusion Duhuozheng pill combined with celecoxib is effective in elderly patients with KOA, and it can decrease the level of IL-1-IL-6IL-8 and improve endothelial function and knee function. It has important research significance.
【作者单位】： 绍兴文理学院附属医院骨科;
【分类号】：R684.3
，

本文编号：1555002