探讨切开减压对挤压综合征家兔模型的疗效

发布时间：2018-03-02 09:53

本文关键词： 切开减压挤压综合征家兔模型疗效　出处：《青海大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察筋膜切开减压术在挤压综合征家兔模型的治疗中能否起到积极作用,并指导临床救治工作。方法:选取健康成年新西兰家兔(不分雌雄)70只。随机分为未行切开减压的实验对照组(10只)和切开减压组(即减压组60只),2组均在挤压4h后解压,减压组根据解压后行筋膜切开减压时间将其分为6个亚组(每个亚组10只):即刻切开组(0h)、2h后切开组、4h后切开组、6h后切开组、8h后切开组及10h后切开组,分别标为A-F组,对照组设为G组;抽取A-G组挤压4h后及减压组(A-F组)减压术后第2h、6h、12h的静脉血,检测血BUN、Cr、AST、ALT、CK、CK-MB、K~+、Ca~(2+)、MYO等生化指标;24小时后取挤压处的肌肉、肾脏、肝脏、心肌立即做切片处理,并在光镜下进行检测分析。结果:各组减压前血BUN、Cr、AST、ALT、CK、CK-MB、K~+、Ca~(2+)、MYO差异无统计学意义(P0.05);两组资料具有可比性。切开减压组与对照组在各时间点生化指标差异均无统计学差异(P0.05);各亚组之间在相同时刻生化指标也无统计学差异(P0.05)。各亚组内随时间变动其BUN、Cr、AST、ALT、CK、CK-MB指标均呈上升趋向;而差异K~+、Ca~(2+)、MYO指标呈下降趋势;有统计学意义(P0.05),有一定的时间依赖性。结论:早期行筋膜切开减压术并不能使挤压综合征家兔模型的各项生化指标得到改善,早期治疗中无明显的疗效;
[Abstract]:Objective: to observe whether fasciotomy and decompression can play an active role in the treatment of rabbit model of squeeze syndrome. Methods: 70 healthy adult New Zealand rabbits (male and female) were randomly divided into control group (n = 10) and decompression group (n = 60) and decompression group (n = 60). The decompression group was divided into 6 subgroups according to the time of fasciotomy decompression after decompression. (10 rats in each subgroup): the immediate incision group was divided into two groups: the immediate incision group was divided into two groups: the immediate incision group was divided into two groups: the immediate incision group was divided into two groups: the immediate incision group was divided into two groups: the immediate incision group was divided into two groups: the immediate incision group was divided into two groups: the immediate incision group (n = 10) and the. The control group was divided into G group, group A-G and group A-F). The venous blood samples were taken from group A-G 4 hours after compression and from group A to F at 2 h after decompression. The blood samples were collected from the muscle, kidney, liver and myocardium of the extruded area 24 hours after operation, and the blood levels of BUN-CrASTK, CK-MBO, KK and MYO were detected immediately after decompression, and the muscle, kidney, liver and myocardium of the extruded area were taken immediately after 24 hours of operation. Results: before decompression, there was no significant difference between the two groups in blood BUNCrASTASTASTORA (KK-MBT) K ~ (+) K ~ (+) K ~ (+) ~ (2) ~ (1) ~ (2) ~ (2) -MYO, the data of the two groups were comparable, and there was no significant difference in biochemical indexes between the open decompression group and the control group at all time points (P < 0. 05), and there was no significant difference between the two groups. There was no significant difference in biochemical indexes between subgroups at the same time (P 0.05). But the difference of MYO index between two groups of K ~ (+) ~ ~ ~. There was no obvious effect in early treatment.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R642;R-332

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