局部应用氨甲环酸对全髋关节置换术失血量及安全性疗效研究

发布时间：2018-03-03 05:14

本文选题：氨甲环酸　切入点：关节成形术　出处：《重庆医学》2017年15期 　论文类型：期刊论文

【摘要】：目的研究局部应用氨甲环酸(TXA)对减少全髋关节置换术(THA)失血量及安全性疗效。方法选取2014年11月至2016年3月该院骨科收治的63例初次行单侧THA患者为研究对象,随机分为2组,A组37例,B组26例。A组于手术缝皮结束后关节腔引流管内注入2.0g TXA(溶于10mL生理盐水)。B组于手术缝皮结束后关节腔引流管内注入同等量的生理盐水。比较两组患者置换前和置换后24、48、72h血红蛋白、红细胞压积,术后失血量,输血量,输血人数,以及置换前和置换后24、48、72h纤维蛋白原、凝血酶原时间及活化部分凝血活酶时间、下肢深静脉彩超。结果 A组患者置换后24、48、72h血红蛋白、红细胞压积、术后失血量、输血量、输血人数均明显优于B组,比较差异有统计学意义(P0.05)。而两组置换前和置换后24、48、72h纤维蛋白原、凝血酶原时间及活化部分凝血活酶时间、下肢深静脉彩超比较差异无统计学意义(P0.05)。结论局部应用TXA可以明显减少THA围术期的失血量且不增加下肢深静脉血栓形成风险。
[Abstract]:Objective to study the effect of local application of TXA on reducing blood loss and safety of total hip arthroplasty. Methods 63 patients with primary unilateral THA were selected from November 2014 to March 2016 in the orthopedic department of our hospital. Two groups were randomly divided into group A (n = 37) and group B (n = 26). Group A (n = 26) was injected with 2.0 g TXA (dissolved in 10 mL saline solution) into the drainage tube of articular cavity after the end of the suture skin. Group B was injected with the same amount of normal saline in the drainage tube of the joint cavity after the end of the suture skin. The hemoglobin levels before and after replacement were compared between the two groups. Hematocrit, blood loss, blood transfusion, number of blood transfusions, fibrinogen, prothrombin time and activated partial thromboplastin time before and after replacement. Results the hemoglobin, hematocrit, blood loss, blood transfusion volume and the number of blood transfusion in group A were significantly better than those in group B. The difference between the two groups was statistically significant (P 0.05), while fibrinogen, prothrombin time and activated partial thromboplastin time were observed before and after the replacement. Conclusion Local application of TXA can significantly reduce the blood loss in perioperative period of THA and do not increase the risk of deep venous thrombosis in lower extremity.
【作者单位】：安徽医科大学附属巢湖医院骨二科;
【分类号】：R687.4

【相似文献】