右美托咪定注射液在女性患者中年龄因素对有效镇静量效关系的影响

发布时间：2018-03-03 08:54

本文选题：年龄　切入点：女性患者　出处：《中国临床药理学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的观察年龄因素对女性患者单次泵注右美托咪定注射液的有效镇静量效关系的影响。方法选取择期腰硬联合麻醉下进行下肢手术女性患者,根据不同年龄分为3组,A组26例(20~35岁)、B组31例(40~60岁)和C组29例(65~79岁)。3组患者待进行腰硬联合麻醉后,开始泵注右美托咪定,各组每例患者的给药剂量由二阶段改良序贯法决定,A组、B组和C组分别以1.0,1.0和0.6μg·kg~(-1)为初始单次剂量泵注,15 min泵完。泵注完毕后对患者进行1次警觉/镇静评分(OAA/S)评分,随后每5 min评估1次,持续15 min。使用Probit逻辑回归法计算3组右美托咪定有效镇静的半数有效剂量(ED50)及其相应的95%置信区间(CI)。结果 A组、B组和C组右美托咪定有效镇静的ED50分别为0.98,0.96,0.66μg·kg~(-1);相应的95%CI分别为0.93~1.03,0.92~1.00和0.63~0.69μg·kg~(-1)。与A组和B组比较,C组ED50明显降低(P0.05)。A组出现心动过缓2例(7.69%),B组出现心动过缓4例(12.90%),C组有心动过缓2例(6.89%),差异无统计学意义(P0.05)。结论中、青年女性患者单次泵注右美托咪定有效镇静的ED50无差异,而老年女性患者的ED50显著低于中青年女性患者。
[Abstract]:Objective to observe the effect of age factors on the effective sedative dose-effect relationship of dexmetomidine injection by single pump in female patients. Methods female patients undergoing lower extremity surgery under selective spinal-epidural anesthesia were selected. According to different ages, patients were divided into three groups: group A (n = 26) and group B (n = 31) and group C (n = 29) and group C (n = 29) and group C (n = 29). The dosage of each patient was determined by the two-stage modified sequential method. Group A, B and C were treated with 1.0 渭 g 路kg ~ (-1) and 0.6 渭 g 路kg ~ (-1), respectively, as the initial single dose pump for 15 min. After the pump was injected, the patients were assessed with an alert / sedation score (OAA / S). They are then evaluated every 5 min, For 15 mins, the Probit logical regression method was used to calculate the half effective dose of dexmetomidine (ED50) and its corresponding 95% confidence interval. Results the ED50 of group A and group C were 0.980.96 渭 g 路kg-1 and 0.66 渭 g 路kg-1, respectively. Compared with group A and group B, the ED50 of group C was significantly lower than that of group A (n = 2) with bradycardia in group B (n = 2) with bradycardia in group B (n = 4) with bradycardia in group C (n = 2). There was no significant difference in ED50 sedation by single pump of dexmetomidine in young women, while ED50 in elderly women was significantly lower than that in young and middle-aged women.
【作者单位】：南方医科大学附属广州军区广州总医院麻醉科;
【基金】：广东省科技计划基金资助项目(2014A020215026) 军队后勤科研计划面上基金资助项目(CGZ15C003)
【分类号】：R614

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