骨细胞力学信号转导功能研究被引最高50篇相关文献分析

发布时间：2018-03-03 12:02

本文选题：骨细胞　切入点：机械应力　出处：《中国骨质疏松杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的本文拟分析和研究骨细胞受机械应力刺激相关方面被引率最高的50篇文献的基本特征,为临床相关研究提供一定的参考。方法计算机检索"Pubmed","Web of Science"等英文数据库,以"Compressive stress,Tensile stress,Fluid shear stress,stretch stress,centrifugal force,Micropipette stimulation,Electromagnetic force mode,Mechanical stress,mechanotransduction"和"osteocyte,osteoblast"为关键词进行检索,筛选出被引频次最高的50篇文献,排除与该研究不相关的其他文献,对文献的标题、第一作者、发表年份、期刊来源、地区分布、作者单位、被引频次等重要信息进行统计分析。结果被引最高的50篇文献的频次从239次到20次,发表于1999年至2015年,其中以2009年最多为9篇,文献刊登于27本期刊,其中以《Journal of Bone and Mineral Research》发表最多(11篇),其次是《Journal of Biological Chemistry》(6篇)、《Bone》(5篇);来源于12个国家,其中美国最多(21篇),发表2篇及2篇以上文献的大学或医院有7家,排名前两名的为印第安纳大学(4篇)、上海交通大学(3篇),共两位作者发表2篇以上文献,研究最多的信号通路依次为MAPK-ERK signaling pathway(11)篇、Wnt/beta-catenin signaling(9篇)、PI3K/AKT signaling pathway(4篇)、BMP signaling pathway(2篇)。结论被引最高文献的分析不仅有助于了解骨细胞机械应力刺激相关研究的发展状况,指导未来研究方向,还可以为广大研究者阅读文献提供参考。
[Abstract]:Objective to analyze and study the basic characteristics of 50 literatures with the highest citation rate in relation to mechanical stress stimulation of bone cells, and to provide some references for clinical research. Methods English databases such as "Pubmed", "Web of Science" and so on were searched by computer. The key words "Compressive stress stress, stress shear stress, stress stress, stress stress, stress stress, stimulation of electromagnetic force stress, mechanical stress, mechanical stress, mechanical introduction" and "osteocyte osteoblast" were used to search for the top 50 cited articles, excluding other papers not relevant to the study. The title, the first author, the year of publication, the source of the journal, were selected. Regional distribution, author's unit, citation frequency and other important information were statistically analyzed. Results the frequency of the top 50 cited articles ranged from 239 times to 20 times, published from 1999 to 2015, of which 9 articles were published in 2009 and published in 27 journals. Among them, "Journal of Bone and Mineral Research" was published most frequently in 11 articles, followed by < Journal of Biological Chemistry > in 6 articles and < Bone > in 5 articles. The top two are four articles from Indiana University and three articles from Shanghai Jiaotong University. Two authors have published more than two articles. The most studied signal pathways were MAPK-ERK signaling pathway 11 (Wnt / beta-catenin signaling(9) and PI3K / AKT signaling pathway(4 (BMP signaling pathway(2). Conclusion the analysis of the highest cited literatures is not only helpful to understand the development of the research on mechanical stress stimulation of bone cells, but also to guide the research direction in the future. It can also provide a reference for researchers to read the literature.
【作者单位】：兰州大学第二医院骨科甘肃省骨与关节疾病重点实验室;
【基金】：国家自然科学基金(81672207) 甘肃省青年科技基金计划(2015GS05051)
【分类号】：R68

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