组织工程化软骨与富血小板血浆复合可促进软骨缺损修复

发布时间：2018-03-08 19:53

  本文选题：组织工程化软骨　切入点：富血小板血浆　出处：《基因组学与应用生物学》2017年09期 　论文类型：期刊论文

【摘要】：为探讨组织工程化软骨与富血小板血浆复合修复软骨缺损的效果,本研究选取了8周龄健康新西兰兔24只,依据随机数表法分为观察组(组织工程化软骨与富血小板血浆复合)和对照组(单纯软骨缺损模型),发现术后4周、8周、12周,观察组实验动物的大体评分均明显高于对照组(p0.05)。观察组实验动物的Collagen TypeⅠ、Collagen TypeⅡ相对表达水平明显高于对照组(p0.05)。两组实验动物的Collagen TypeⅩ相对表达水平无显著差异(p0.05)。观察组实验动物的软骨缺损直径和缺损深度分别为(1.02±0.35)mm、(0.96±0.27)mm,对照组实验动物的软骨缺损直径和缺损深度分别为(4.27±1.09)mm、(5.43±1.85)mm(p0.05),表明组织工程化软骨与富血小板血浆复合修复软骨缺损效果明显,能够刺激软骨相关基因表达,缩小软骨缺损范围,促进缺损软骨愈合。
[Abstract]:In order to investigate the effect of tissue engineered cartilage and platelet-rich plasma on repairing cartilage defects, 24 8-week-old healthy New Zealand rabbits were selected in this study. According to the random number table method, the patients were divided into observation group (tissue engineered cartilage combined with platelet-rich plasma) and control group (simple cartilage defect model). The gross scores of experimental animals in the observation group were significantly higher than those in the control group, and the relative expression level of Collagen Type 鈪，

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