补肾散寒通络汤联合艾灸及塞来昔布治疗膝骨关节炎的临床观察

发布时间：2018-03-09 16:11

  本文选题：补肾散寒通络汤　切入点：艾灸　出处：《中国药房》2017年26期 　论文类型：期刊论文

【摘要】：目的:观察补肾散寒通络汤联合艾灸及塞来昔布治疗膝骨关节炎(KOA)的临床疗效及安全性。方法:选取2014年5月-2015年12月在重庆康华医院就诊的KOA患者70例,按照就诊单双号顺序分为对照组和观察组,各35例。对照组患者给予塞来昔布胶囊0.2 g,qd;观察组患者在对照组基础上加用补肾散寒通络汤(每日1剂,水煎取汁300 mL,分早、中、晚3次服用)及艾灸治疗。两组患者均以4周为1个疗程,连续治疗2个疗程。比较两组患者的临床疗效,治疗前后的中医证候积分、视觉模拟评分法(VAS)评分、西安大略和麦克马斯特大学量表(WOMAC)评分、实验室检查指标、关节情况,以及不良反应发生情况。结果:观察组患者的总有效率(85.71%)显著高于对照组(68.57%),差异有统计学意义(P0.05)。治疗前,两组患者的上述指标比较,差异均无统计学意义(P0.05)。治疗后,两组患者的中医证候积分、VAS评分、WOMAC评分、红细胞沉降率、C反应蛋白水平和膝关节肿胀积分均较治疗前显著降低,且观察组各指标水平显著低于对照组,差异均有统计学意义(P0.05);两组患者治疗前后骨摩擦音关节个数比较,差异均无统计学意义(P0.05)。两组患者不良反应发生率比较(5.71%vs.2.86%),差异无统计学意义(P0.05)。结论:补肾散寒通络汤联合艾灸及塞来昔布能改善KOA患者临床症状,缓解关节疼痛,减轻关节炎症和肿胀,且用药较安全。
[Abstract]:Objective: To observe the effect of Bushen Tongluo decoction combined with cold moxibustion and celecoxib in the treatment of knee osteoarthritis (KOA) clinical efficacy and safety. Methods: May 2014 -2015 year in December 70 cases of Chongqing Hong Wah hospital KOA patients according to clinical single, randomly divided into control group and observation group, 35 cases in each 0.2. The control group were treated with Celecoxib Capsules g, QD; patients in the observation group in the control group based on the use of Bushen Tongluo Decoction (cold dispelling agent 1, daily Decoction 300 mL, early, late, 3 doses) and moxibustion treatment. Two patients were in 4 weeks as 1 course. Continuous 2 courses of treatment. The clinical efficacy of two groups were compared before and after treatment, TCM syndrome score, visual analogue scale (VAS) score, Xi'an and Ontario McMaster University scale (WOMAC) score, laboratory examination indexes, joint, and adverse reactions. Results: the patients in the observation group The total effective rate (85.71%) was significantly higher than the control group (68.57%), the difference was statistically significant (P0.05). Before the treatment, comparing the index of the two groups, there were no significant differences (P0.05). After treatment, the TCM syndromes, two groups of patients with VAS score, WOMAC score, red blood cell sedimentation rate, C reactive protein level and the knee joint swelling score were significantly lower than those before treatment, and the observation group each index level was significantly lower than the control group, the differences were statistically significant (P0.05); bone fricative joint number of two groups of patients before and after treatment, there were no significant differences (P0.05) occurred in two patients. The adverse reaction rate (5.71%vs.2.86%), the difference was not statistically significant (P0.05). Conclusion: Bushen Tongluo decoction combined with cold moxibustion and celecoxib can improve the clinical symptoms of KOA patients, relieve joint pain, reduce joint inflammation and swelling, and the drug is safe.

【作者单位】： 重庆医科大学中医药学院;西南医科大学临床医学院;重庆康华医院中医科;
【基金】：国家自然科学基金(青年科学基金)资助项目(No.81674002)
【分类号】：R684.3
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本文编号：1589263