乳腺癌内乳淋巴结转移相关危险因素研究

发布时间：2018-03-10 10:24

  本文选题：乳腺癌　切入点：内乳淋巴结　出处：《苏州大学》2015年硕士论文　论文类型：学位论文

【摘要】：研究目的探讨乳腺癌内乳淋巴结转移相关危险因素,强调内乳淋巴结在乳腺癌分期及预后有着非常重要的临床意义,根据内乳淋巴结转移的风险因素,为今后研究内乳淋巴结活检的临床意义。方法我们从上海瑞金医院乳腺肿瘤中心,回顾性分析142例乳腺癌扩大根治术临床资料,选取病人年龄、肿瘤T分期、最终肿瘤大小、肿瘤位置、肿瘤病理分类、激素受体、淋巴管浸润及腋窝淋巴结转移状况共8个与乳腺癌内乳淋巴结转移可能相关的因素,采用统计方法Χ2检验和秩和检验(P=0.05)。结果选取的22例乳腺癌内乳淋巴结转移的患者中,内乳淋巴结转移相关的8个危险因素中,肿瘤的T分期(P0.1)、肿瘤的位置(P=0.25,P0.1)、肿瘤病理(0.1)、及激素受体(ER P=0.9,PR P=0.6)不是影响内乳淋巴结转移的独立因素(P0.05)。而与患者的年龄(P0.001)、淋巴管浸润(P=0.01)、最终肿瘤大小(P=0.025)和腋窝淋巴结阳性(P0.005)相关(P0.05),并且腋窝淋巴结阳性个数≥4的患者较4个患者发生内乳淋巴结转移有着明显差异(P0.005)。结论142例患者中,内乳淋巴结阳性22例(15.5%),具有淋巴管浸润、最终肿瘤越小、腋窝淋巴结阳性且阳性个数≥4的年轻病人是内乳淋巴结转移的高危患者。
[Abstract]:Objective to investigate the risk factors associated with intramammary lymph node metastasis in breast cancer, and to emphasize that internal mammary lymph node plays an important role in the staging and prognosis of breast cancer. Methods the clinical data of 142 patients with breast cancer undergoing extended radical mastectomy were retrospectively analyzed from the breast tumor center of Ruijin Hospital in Shanghai. The patients' age, T stage and final tumor size were selected. Tumor location, pathological classification, hormone receptor, lymphatic invasion and axillary lymph node metastasis were 8 possible factors associated with breast cancer intramammary lymph node metastasis. Results among 22 breast cancer patients with intramammary lymph node metastasis, 8 risk factors were associated with internal mammary lymph node metastasis. The T staging of the tumor, the location of the tumor, the location of the tumor, the pathology of the tumor, and the hormone receptor ER P0. 9 / PR P0. 6) are not independent factors affecting the metastasis of the medial mammary lymph node, but not the age of the patient (P 0. 001, lymphatic vessel infiltrating P 0. 01, and ultimately the size of the tumor P0. 025) and axillary lymph node. There were significant differences in the incidence of intramammary lymph node metastasis in patients with positive number of axillary lymph nodes (鈮，

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