负压引流联合纳米银敷料促进感染切口愈合的实验及临床研究

发布时间：2018-03-11 10:08

本文选题：自制负压装置　切入点：纳米银敷料　出处：《中国感染控制杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨自制负压装置联合纳米银敷料促进大鼠切口感染愈合的优势,并探究其临床疗效。方法感染切口模型大鼠随机分为常规处理组、单纯负压吸引组、负压吸引联合银离子敷料组。治疗后评价各组大鼠切口愈合时间、愈合面积,对切口组织的炎症因子进行免疫组化及荧光定量分析。并将三组方法应用于临床手术部位感染患者,比较分析各组患者切口的肉芽覆盖时间、肉芽痊愈时间和切口愈合时间。结果大鼠肉芽组织免疫组织化学及IOD值、大鼠切口组织TNF-α、IL-2、IL-8的mRNA相对表达水平均低于常规处理组和单纯负压吸引组,差异有统计学差异(P0.05);临床应用中负压吸引联合银离子敷料组的切口愈合时间、术后C反应蛋白、疼痛评分等指标均优于常规处理组和单纯负压吸引组,差异有统计学差异(均P0.05)。结论与传统治疗手段相比,负压吸引联合银离子敷料治疗能更有效地控制手术部位感染,减轻切口局部炎症,促进切口愈合。
[Abstract]:Objective to explore the advantages of self-made negative pressure device combined with nano-silver dressing in promoting wound infection healing in rats and to explore its clinical efficacy. Methods Rats with infected incision model were randomly divided into conventional treatment group and simple negative pressure suction group. After treatment, the wound healing time and healing area of rats in each group were evaluated. The inflammatory factors of incision tissue were analyzed by immunohistochemistry and fluorescence quantitative analysis. Results Immunohistochemistry and IOD of granulation tissue and the relative expression of TNF- 伪 IL-2IL-8 in rat incision tissue were lower than those in conventional treatment group and simple negative pressure suction group. In clinical application, the wound healing time, postoperative C-reactive protein and pain score of the negative pressure suction combined with silver ion dressing group were better than those of the conventional treatment group and the simple negative pressure suction group. Conclusion compared with the traditional treatment, the negative pressure suction combined with silver ion dressing can effectively control the infection of the surgical site, reduce the local inflammation of the incision and promote the wound healing.
【作者单位】：湘潭市第一人民医院;南华大学护理学院;贵州医科大学护理学院;
【基金】：湖南省湘潭市科技计划项目(S2015S0013)
【分类号】：R619.3

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