胃肠道恶性肿瘤与非恶性肿瘤老年患者认知功能的研究

发布时间：2018-03-14 21:04

本文选题：胃肠道恶性肿瘤　切入点：听觉词语学习测验(AVLT)　出处：《福建医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的对比分析老年胃肠道恶性肿瘤与非恶性肿瘤老患者认知功能的差别,为临床的进一步研究防治术后认知功能障碍提供前期研究结果。方法采用听觉词语学习测验(AVLT)和画钟实验(CDT)两种神经心理测验方法,对2014年11月至2015年1月期间在福建医科大学附属协和医院住院的73名60岁至80岁的胃肠道恶性肿瘤老年患者(A组)与47名同年龄段的非恶性肿瘤老年患者(B组)的认知功能进行评估,并记录患者的临床资料,包括病案号、年龄、性别、受教育程度、内科合并症等,两组患者的基本资料以及评估结果根据正态性检验结果分别利用独立样本t检验、卡方检验、秩和检验和R*C表资料的卡方检验进行统计学分析,进一步比较二者间的差异。结果A、B两组病例在年龄、性别组成、受教育程度及内科合并症等方面的差异无统计学意义(P0.05);A组的短时刻记忆(AVLT-1、AVLT-2、AVLT-3、AVLT-I)、短延迟回忆(AVLT-4)与AVLT总分明显低于B组,A组的认知功能障碍发生率(43.83%)明显高于B组(25.53%),差异均有统计学意义(P0.05),但A组患者的长延迟记忆得分(AVLT-5)、AVLT-E、AVLT再认及CDT得分与B组的差异无统计学意义(P0.05)。结论胃肠道恶性肿瘤患者认知功能损害较非恶性肿瘤患者明显,且认知损害主要表现在短时刻记忆和短延迟回忆。
[Abstract]:Objective to compare and analyze the difference of cognitive function between elderly patients with gastrointestinal malignancies and those with non-malignant tumors. Methods two neuropsychological test methods: auditory word learning test (AVLT) and bell drawing test (CDT) were used. From November 2014 to January 2015, 73 elderly patients aged 60 to 80 with gastrointestinal malignancies were hospitalized in Union Hospital of Fujian Medical University) and 47 non-malignant elderly patients of the same age were treated with Group B). To assess cognitive function, The clinical data of the patients were recorded, including medical record number, age, sex, education level, medical complications and so on. The basic data and evaluation results of the two groups were tested by independent sample t test and chi-square test according to the results of normality test. Rank sum test and chi-square test were used to further compare the difference between the two groups. Results the age, sex composition of two groups of patients were analyzed. There was no significant difference in education level and complication of internal medicine. The total scores of AVLT-1, AVLT-2, AVLT-3, AVLT-4 and AVLT in group A were significantly lower than those in group B (43.833) and significantly higher than that in group B (25.533.35), and the total scores of AVLT-4 and AVLT in group A were significantly lower than those in group B (43.833). There was no significant difference between group A and group B in the recognition of AVLT-E AVLT and the scores of CDT. Conclusion the cognitive impairment in patients with gastrointestinal malignancy is significantly higher than that in patients with non-malignant tumors. And cognitive impairment mainly manifested in short-time memory and short-delayed memory.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R614;R735

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