超声中频介导药物治疗关节痛137例的临床观察

发布时间：2018-03-15 09:42

本文选题：超声介导药物靶向递送技术　切入点：疼痛视觉模拟评分　出处：《重庆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：探讨超声介导药物靶向递送技术对关节痛的治疗效果与安全性。方法：将关节疼痛患者随机分为治疗组137例和对照组138例,治疗组采用超声中频导药仪治疗,对照组采用电脑中频治疗仪治疗,两组患者每次均治疗20分钟,每天1次,10天为1个疗程,共治疗3个疗程。采用疼痛视觉模拟评分(VAS)观察两组患者治疗前后疼痛情况,根据关节功能分级判断治疗前后关节功能改善情况,同时检测治疗前后红细胞沉降率(ESR)、C-反应蛋白(CRP)、血常规、肝功能、肾功能,并观察治疗局部不适。结果：治疗组VAS评分总有效率为92.70%,对照组VAS评分总有效率为81.88%,两组差异具有统计学意义(P0.05)；治疗组关节功能改善64例,明显优于对照组43例,两组比较差异具有统计学意义(P0.05)；治疗后两组患者ESR、CRP较治疗前均有明显下降(P0.05),两组患者CRP和ESR下降幅度差异无统计学意义(P0.05)；治疗前后检测两组患者血常规、肝肾功未见异常,两组患者治疗局部未见皮疹、瘙痒等不适。结论：超声介导药物靶向递送技术可安全有效缓解关节炎性疼痛,改善关节功能,值得推广。
[Abstract]:Objective: to investigate the efficacy and safety of ultrasound mediated drug targeting delivery in the treatment of joint pain. Methods: 137 patients with joint pain were randomly divided into treatment group (n = 137) and control group (n = 138). The patients in the control group were treated with a computer medium frequency therapeutic instrument. The patients in both groups were treated for 20 minutes each time, once a day for 10 days as a course of treatment for a total of 3 courses of treatment. The pain status before and after treatment was observed by visual analogue score of pain (VASS). According to the grade of joint function, the improvement of joint function was judged before and after treatment, and the erythrocyte sedimentation rate before and after treatment was detected, and the blood routine, liver function and renal function were detected. Results: the total effective rate of VAS score in the treatment group was 92.70, the total effective rate in the control group was 81.880.The difference between the two groups was statistically significant (P 0.05), and the joint function of the treatment group was improved in 64 cases, which was significantly better than that in the control group (43 cases). The difference between the two groups was statistically significant (P 0.05). After treatment, the levels of CRP and ESR in the two groups were significantly lower than those before and after treatment. There was no significant difference in the decrease of CRP and ESR between the two groups (P 0.05). The blood routine examination of the two groups before and after treatment showed no abnormality in liver and kidney function, and there was no significant difference between the two groups before and after treatment. Conclusion: Ultrasound-mediated drug targeting delivery technique is safe and effective in relieving arthritis pain and improving joint function, which is worth popularizing.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R684

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