富血小板血浆治疗椎间盘退变:从基础研究到临床应用

发布时间：2018-03-18 01:15

  本文选题：富血小板血浆　切入点：椎间盘退化　出处：《中国组织工程研究》2017年32期 　论文类型：期刊论文

【摘要】：背景:椎间盘退变是下腰痛的常见原因,椎间盘内的微环境和细胞环境发生变化是诱发椎间盘退变的重要因素,但目前仍无确凿证据表明退变发生的机制。目的:针对当前富血小板血浆治疗椎间盘退变的研究概况做一综述。方法:设计综述的撰写结构,在万方数据库和Pub Med数据库中分别输入中、英文检索词,分析所得文献的摘要及内容,通过纳入和排除得到相关文献。结果与结论:尽管手术治疗中晚期椎间盘退变有显著疗效,但对于早期退变,仍没有较好的保守治疗方法。富血小板血浆可以促进组织愈合和再生,已被诸多学者用于椎间盘退变模型的治疗中。细胞学实验及动物实验证明,富血小板血浆可以有效延缓甚至逆转椎间盘早期退变;临床试验表明,下腰痛患者接受富血小板血浆治疗后疼痛有所改善,将富血小板血浆和其他生物学治疗结合,能够显著改善椎间盘退变。目前的大多数实验都局限于细胞学和动物学研究,临床治疗的报道少之又少,加之富血小板血浆的提取方法、注射剂量以及最佳注射时间都无统一标准,而对富血小板血浆治疗的不良反应也知之甚少,故富血小板血浆治疗椎间盘退变的疗效有待于进一步验证。
[Abstract]:Background: disc degeneration is a common cause of low back pain. The changes of microenvironment and cellular environment in intervertebral disc are important factors to induce disc degeneration. But there is still no conclusive evidence to indicate the mechanism of degeneration. Objective: to review the current research of platelet-rich plasma in the treatment of disc degeneration. Input Chinese and English key words in Wanfang database and Pub Med database, analyze the abstracts and contents of the literature, Results and conclusions: although the surgical treatment of intervertebral disc degeneration in the middle and late stage has a significant effect, it is effective in the early stage of degeneration. Platelet-rich plasma can promote tissue healing and regeneration, and has been used by many scholars in the treatment of intervertebral disc degeneration model. Cytological and animal experiments have proved that platelet rich plasma can promote tissue healing and regeneration. Platelet rich plasma can effectively delay or even reverse the early degeneration of intervertebral disc. Clinical trials show that the pain of patients with low back pain after treatment with platelet-rich plasma can be improved by combining platelet-rich plasma with other biological treatments. Most of the current experiments are limited to cytological and zoological studies, with few reports of clinical treatment and methods of extracting platelet-rich plasma. There is no uniform standard for injection dose and optimal injection time, and little is known about the adverse reactions of platelet-rich plasma therapy, so the efficacy of platelet-rich plasma in treating disc degeneration needs further verification.
【作者单位】： 东南大学医学院;东南大学附属中大医院骨科;
【基金】：国家自然科学基金(81572188)~~
【分类号】：R681.5
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本文编号：1627340