椎间盘退变前驱因素终板退变研究现状

发布时间：2018-03-20 14:40

本文选题：终板　切入点：椎间盘退变　出处：《中华中医药杂志》2017年09期 　论文类型：期刊论文

【摘要】：明确终板在椎间盘的生理和退变过程中起的作用,对相关知识进行综述。查阅近10年来关于终板与椎间盘退变的文献,整合相关知识,围绕终板及其退变过程对椎间盘退变作出新的解释。结果发现终板可以分为骨性终板和软骨终板,位于椎体和椎间盘之间,起着保护椎体和椎间盘、营养椎间盘的作用。由于基因、年龄、力学负载、损伤等众多因素导致终板的保护作用下降甚至丧失,椎间盘的主要营养通路破坏,终板发生退变,软骨终板钙化,边缘不规则,进而出现椎间隙狭窄、骨赘形成,影像学上出现Modic改变,临床上出现腰痛的症状。终板是椎体-终板-椎间盘系统的重要组成部分,无论对椎体还是椎间盘都有着至关重要的作用。终板退变可能是椎间盘退变的前驱变化,研究终板退变的机制将会对阐明椎间盘退变的机制有重要的意义。
[Abstract]:To clarify the role of endplate in the physiology and degeneration of intervertebral disc, and to review the relevant knowledge of endplate and intervertebral disc degeneration in the past 10 years. A new explanation of intervertebral disc degeneration is given around the endplate and its degenerative process. The results show that the endplate can be divided into bony endplate and cartilage endplate, located between the vertebral body and the intervertebral disc, which protects the vertebral body and the intervertebral disc. The role of vegetative disc. Due to many factors such as gene, age, mechanical load, injury and so on, the protective effect of endplate is decreased or even lost, the main nutritional pathway of disc is destroyed, endplate degeneration, cartilage endplate calcification, etc. The margin is irregular, resulting in narrow intervertebral space, osteophyte formation, imaging changes in Modic, and clinical symptoms of low back pain. The endplate is an important part of the vertebro-endplate intervertebral disc system. Degenerative endplate degeneration may be the precursor of disc degeneration, and studying the mechanism of endplate degeneration will be of great significance to clarify the mechanism of intervertebral disc degeneration.
【作者单位】：浙江中医药大学骨伤研究所;浙江省立同德医院;
【基金】：国家自然科学基金项目(No.81273770,No.81373669) 浙江省自然科学基金项目(No.LZ12H270001,No.LY15H270012) 浙江省中西医结合骨关节病研究科技创新团队(No.2011R50022) 浙江省骨关节疾病中医药干预技术研究重点实验室(No.2013E10024)~~
【分类号】：R681.53

【相似文献】