槐耳颗粒对乳腺癌术后化疗患者免疫功能及生活质量的影响

发布时间：2018-03-21 04:43

本文选题：乳腺癌　切入点：槐耳颗粒　出处：《东南大学学报(医学版)》2017年04期 　论文类型：期刊论文

【摘要】：目的:探讨槐耳颗粒对乳腺癌术后化疗患者外周血细胞免疫功能及生活质量的影响。方法:将90例乳腺癌术后患者随机分为治疗组和对照组。治疗组行"FEC"(环磷酰胺0.6 g·m~(-2),d1;表柔比星100 mg·m~(-2),d1;氟尿嘧啶0.6 g·m~(-2),d1)方案化疗,同时给予槐耳颗粒口服,20 g·次-1,3次·d~(-1),连续服用2个月;对照组单纯行"FEC"方案化疗。2周期后对患者生活质量、临床症状及免疫功能进行评价。结果:两组患者治疗前外周血NK细胞、CD3~+、CD4~+、CD4~+/CD8~+值差异无统计学意义;2周期后治疗组各项免疫指标明显优于对照组,差异具有统计学意义(P0.05)。在改善中医症候群和提高生活质量评分中,治疗组明显高于对照组,差异具有统计学意义(P0.05)。结论:槐耳颗粒能提高乳腺癌术后化疗患者的免疫功能,改善临床症状,提高生活质量,值得临床进一步研究。
[Abstract]:Objective: To investigate the effect of Huaier Granule on chemotherapy in patients with peripheral blood cell immune function and quality of life in patients with breast cancer. Methods: 90 cases of postoperative breast cancer patients were randomly divided into treatment group and control group. The treatment group received FEC (cyclophosphamide 0.6 g - m~ (-2), D1; epirubicin 100 star mg m~ (-2), D1 g m~ 0.6; fluorouracil (-2), D1) chemotherapy, while giving oral Huaier Granule 20 G times, -1,3 times, d~ (-1), taking 2 consecutive months; the quality of life of the patients in control group underwent FEC regimen in.2 cycle after the evaluation of clinical symptoms and immune function. Results: two groups of patients before treatment of peripheral blood NK cells, CD3~+, CD4~+, CD4~+/CD8~+ were no significant difference; after 2 cycles of treatment group the immune indexes were significantly better than the control group, the difference was statistically significant (P0.05). The improvement of TCM syndrome and improve the quality of life the score in the treatment group was significantly higher than that of The control group, the difference was statistically significant (P0.05). Conclusion: Huaier Granule on immune function in patients with chemotherapy of breast cancer after surgery, improve clinical symptoms, improve the quality of life, and is worthy of further study.

【作者单位】：三峡大学第一临床医学院肿瘤防治中心/宜昌市中心人民医院肿瘤科;武汉市中心医院/武汉市肿瘤研究所;中山大学肿瘤防治中心;
【基金】：湖北省自然科学基金面上项目(2014CFB675) 湖北省教育厅重点项目(D20141205) 湖北省卫计委科研基金面上项目(WJ2015MB176)
【分类号】：R737.9

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