右美托咪定对肺癌手术患者免疫功能和微循环的影响

发布时间：2018-03-21 13:09

本文选题：右美托咪定　切入点：肺癌手术　出处：《中国药房》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨右美托咪定对肺癌手术患者免疫功能和微循环的影响。方法:选择择期行肺癌手术患者88例,按随机数字表法分为观察组和对照组,各44例。观察组患者麻醉诱导前10 min静脉注射右美托咪定负荷剂量1μg/kg,并以0.6μg/(kg·h)静脉滴注至关胸;对照组患者静脉注射等量0.9%氯化钠注射液。观察两组患者麻醉诱导开始时(T_0)、手术结束即刻(T_1)、术后12 h(T_2)时的CD3~+、CD4~+、CD8~+水平及CD4~+/CD8~+、末梢灌注指数(TPI)、低频功率(LF)/高频功率(HF)值,并比较两组患者不良反应发生情况。结果:T_0时,两组患者CD3~+、CD4~+、CD8~+、CD4~+/CD8~+、TPI、LF/HF比较,差异均无统计学意义(P0.05)。T_1、T_2时,对照组患者CD3~+、CD4~+、CD4~+/CD8~+、TPI显著降低,且显著低于观察组;CD8~+显著升高,且显著高于观察组;两组患者LF/HF均显著降低,且观察组显著低于对照组,差异均有统计学意义(P0.05)。观察组患者的CD3~+、CD4~+、CD8~+、CD4~+/CD8~+、TPI治疗前后比较,差异均无统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:右美托咪定可有效稳定肺癌手术患者术中的免疫功能和微循环,且不增加不良反应。
[Abstract]:Objective: to investigate the effect of dexmetomidine on immune function and microcirculation in patients with lung cancer. Methods: 88 patients with lung cancer were randomly divided into observation group and control group. 44 patients in each group were given dexmetomidine loading dose of 1 渭 g / kg 10 min before anesthesia induction, and 0.6 渭 g / kg / kg 路h) was injected intravenously to the closed chest. 0.9% sodium chloride injection was injected intravenously in the control group. The levels of CD3 ~ + CD4 ~ + CD8 ~, peripheral perfusion index, low-frequency power LFL / high-frequency power were measured at the beginning of anesthesia induction, and immediately after operation, and 12 hours after operation, the levels of CD3 ~ + CD4 ~ + CD8 ~, peripheral perfusion index and low-frequency power LFF / high-frequency power were measured. Results there was no significant difference between the two groups when CD3 ~ + CD4 ~ + CD8 ~ + CD8 ~ / CD8 ~ + TPII / HF was compared, and there was no significant difference between the two groups at the time of P0.05 ~ + T _ 1 + T _ 1 / T _ 2, while in control group, CD3 ~ CD _ 4 ~ CD _ 4 ~ / CD _ 8 ~ TPI was significantly lower than that in the observation group, and it was significantly higher than that in the observation group (P _ (0.05) ~ + T _ (1) + T _ (1) + T _ (2)), and was significantly lower than that in the observation group (P < 0.05). The LF/HF of the two groups was significantly lower than that of the control group, and the difference was statistically significant (P 0.05). Before and after treatment, the patients in the observation group were compared with the control group before and after treatment. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: dexmetomidine can effectively stabilize the immune function and microcirculation in patients with lung cancer, and does not increase the adverse reactions.
【作者单位】：河南大学第一附属医院麻醉科;
【基金】：河南省卫生厅医学科技攻关计划项目(No.201404023)
【分类号】：R614;R734.2

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