人工关节置换后不同磨损颗粒对全身多系统的影响

发布时间：2018-03-22 20:51

本文选题：假体和植入物　切入点：关节成形术　出处：《中国组织工程研究》2016年53期 　论文类型：期刊论文

【摘要】：背景:研究显示磨损颗粒可导致假体无菌性松动,并播散至全身对全身多系统产生影响。目的:对磨损颗粒的产生、特性、转移至全身的途径及不同磨损颗粒对全身多系统影响的研究现状及新进展做一综述。方法:计算机检索CNKI和PubMed数据库中1999年1月至2016年4月关于人工关节置换后磨损颗粒的文章,排除其中磨损颗粒对假体松动相关文章,中文检索关键词为"磨损颗粒",英文检索关键词"wear particles"。结果与结论:无论人工关节置换采用何种固定方式或采用何种材质假体,假体之间的摩擦和假体与骨界面之间的微动都会产生磨损颗粒。目前还没有发现骨水泥、聚乙烯、陶瓷磨损颗粒对人体短期影响而导致的临床并发症。相比之下,金属磨损颗粒引起的全身反应比较多见,其产生的金属离子不仅对全身多系统产生影响,长期累积还可对人体造成损伤。如今关于假体置换磨损颗粒相关机制的研究多为体外细胞层面研究,却少有完整动物模型层面上的分析,学者们普遍认为颗粒介导的疾病具有长期潜伏期,暴露于金属颗粒后的长期影响仍然不清楚,需要不断探究。
[Abstract]:Background: studies have shown that wear particles can lead to aseptic loosening of the prosthesis and spread throughout the body to have an effect on multiple systems throughout the body. A review of the approaches to systemic transfer and the effects of different wear particles on the multisystem of the whole body was made. Methods: a computer search of CNKI and PubMed databases on the effects of artificial joint replacement from January 1999 to April 2016 was conducted. Articles on wear particles, The key words were "wear particles" in Chinese and "wear particles" in English. Results & conclusion: no matter what kind of fixation or material prosthesis is used in artificial joint replacement, Friction between prostheses and fretting between prosthesis and bone interface can produce wear particles. There are no clinical complications caused by short-term effects of cement, polyethylene and ceramic wear particles on human body. The whole body reaction caused by metal wear particles is more common, and the metal ions produced by metal particles not only have an effect on the whole body multi-system, Long-term accumulation can also cause damage to the human body. Nowadays, most of the studies on the mechanism of prosthesis replacement wear particles are at the cell level in vitro, but there is little analysis at the level of complete animal models. It is widely believed that particle-mediated disease has a long incubation period and the long-term effects of exposure to metal particles are still unclear and need to be explored continuously.
【作者单位】：兰州大学第二医院;解放军兰州军区兰州总医院骨科;临潭县第一人民医院外科;
【基金】：国家自然科学基金资助项目(81371983) 甘肃省自然科学基金资助项目(1308RJZA146)~~
【分类号】：R687.4

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