缺血性腰椎间盘退变模型兔的磁共振T1ρ和T2mapping成像评价

发布时间：2018-03-23 17:12

  本文选题：磁共振成像　切入点：椎间盘　出处：《中国组织工程研究》2017年31期

【摘要】：背景:磁共振T1ρ和T2mapping成像技术已用于研究人类和恒河猴腰椎间盘退变并认为可以早期评价腰椎间盘退变情况,目前尚无应用磁共振T1ρ和T2mapping成像技术研究新西兰兔腰椎间盘退变的报道。目的:比较不同时间点新西兰兔缺血性腰椎间盘退变模型的磁共振T1ρ和T2-map弛豫时间值,评价两种成像技术对退变评估的敏感性差异。方法:15只新西兰兔随机平均分成3组,每只兔随机干预L_(4-5)、L_(5-6)或L_(6-7)椎间盘中的一个作为缺血性退变模型组,另外2个不干预椎间盘作为空白对照组。所有动物于术前行磁共振T1ρ和T2mapping扫描,3组兔分别于术后1,3或6个月再行相应磁共振扫描,分析两种成像技术在不同时间点弛豫时间值变化。结果与结论:(1)模型组腰椎间盘髓核组织术前T2-map弛豫时间值(146.21±16.93)ms与造模后3个月(118.53±20.51)ms或6个月(85.42±11.65)ms比较,差异有显著性意义(P0.05);而与造模后1个月比较,差异无显著性意义(P0.05);(2)模型组椎间盘髓核组织术前T1ρ弛豫时间值(87.88±8.87)ms与造模后6个月(64.75±14.63)ms比较,差异有显著性意义(P0.05);而与造模后1个月或3个月比较,差异无显著性意义(P0.05);(3)对照组椎间盘髓核组织T1ρ和T2-map弛豫时间值各时间点差异均无统计学意义(P0.05)。造模后6个月兔腰椎间盘磁共振T2WI才出现PfirrmannⅡ-Ⅲ级的改变;(4)结果说明:磁共振T1ρ和T2mapping成像技术可用于量化评价新西兰兔缺血性腰椎间盘退变过程,T2mapping成像可能比T1ρ成像对新西兰兔缺血性退变的早期评估更敏感些。
[Abstract]:Background: magnetic resonance T1 蟻 and T2mapping imaging techniques have been used to study lumbar disc degeneration in human and rhesus monkeys. Up to now, there are no reports on the study of lumbar disc degeneration in New Zealand rabbits using magnetic resonance T1 蟻 and T2mapping imaging techniques. Objective: to compare the magnetic resonance T1 蟻 and T2-map relaxation time of ischemic lumbar disc degeneration models in New Zealand rabbits at different time points. Methods Fifteen New Zealand rabbits were randomly divided into three groups, one of which was randomly treated with L _ (4) -5 / L _ (5-6) or L _ (6 ~ 7) as an ischemic degeneration model group. The other two non-interventional intervertebral discs were used as blank control group. All rabbits received MRI T1 蟻 and T2mapping scan before operation. The changes of relaxation time at different time points by two imaging techniques were analyzed. Results and conclusions the T2-map relaxation time before operation of lumbar disc nucleus pulposus was 146.21 卤16.93)ms in model group and 118.53 卤20.51)ms or 85.42 卤11.65)ms in 6 months after modeling. The difference was significant (P 0.05), but there was no significant difference between the model group and the model group after 1 month. There was no significant difference between the model group and the model group. The T1 蟻 relaxation time before operation was 87.88 卤8.87)ms in the model group and 64.75 卤14.63)ms at 6 months after the model. The difference was significant (P 0.05), and compared with that of 1 month or 3 months after modeling. There was no significant difference in T1 蟻 and T2-map relaxation time between the control group and the control group (P 0.05). The changes of Pfirrmann 鈪，

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