丙泊酚注射液与地佐辛注射液对全麻下手术患者术后苏醒期躁动及术后镇痛的影响

发布时间：2018-03-24 02:23

本文选题：丙泊酚注射液　切入点：芬太尼注射液　出处：《中国临床药理学杂志》2017年19期

【摘要】：目的观察丙泊酚与地佐辛对全麻下手术患者术后苏醒期躁动及术后疼痛的效果。方法将52例全麻下手术的患者随机分为对照组及试验组,各26例。手术结束前15 min,对照组给予地佐辛0.15 mg·kg~(-1)+芬太尼0.6μg·kg~(-1),静脉注射;试验组给予地佐辛0.15 mg·kg~(-1)+丙泊酚2.0 mg·kg~(-1),静脉注射。比较2组患者术后睁眼时间、拔管时间、拔管时的平均动脉压、心率、镇静、疼痛评分及安全性。结果手术后,对照组和试验组患者睁眼时间分别为(13.28±0.63)和(9.21±0.37)min,对照组和试验组拔管时间分别为(17.23±1.14)和(13.74±1.02)min,对照组和试验组平均动脉压分别为(97.64±9.34)和(90.13±7.32)mm Hg,对照组和试验组心率分别为(86.34±5.27)和(78.46±6.47)time·min~(-1),差异均有统计学意义(均P0.05)。对照组和试验组镇静和躁动评分分别为(5.03±0.45)和(3.49±0.17)分;视觉模拟评分(VAS)分别为(4.23±0.24)和(2.11±0.16)分,差异均有统计学意义(均P0.05)。对照组药物不良反应有头晕、恶心呕吐,药物不良反应发生率为11.54%(3/26例);试验组药物不良反应有恶心、呕吐、低血压,药物不良反应发生率为7.69%(2/26例),差异无统计学意义(P0.05)。结论与芬太尼复合地佐辛比较,丙泊酚联合地佐辛能够明显减轻全麻下神经外科手术患者术后苏醒期躁动及疼痛程度,稳定拔管时平均动脉压、心率,并且不延长苏醒及拔管时间,安全性较高。
[Abstract]:Objective to observe the effect of propofol and dizosin on postoperative restlessness and postoperative pain in patients undergoing general anesthesia. There were 26 cases in each group. 15 min before operation, the control group was given dizosin 0.15 mg / kg, fentanyl 0.6 渭 g / kg, fentanyl was intravenously injected, while the experimental group was given dizosin 0.15 mg / kg / kg / 1) propofol 2.0 mg / kg / kg / L, intravenously. The time of eye opening and extubation were compared between the two groups. Mean arterial pressure, heart rate, sedation, pain score and safety at extubation. The time of eye opening was 13.28 卤0.63) and 9.21 卤0.37 min in the control group and the experimental group, respectively. The extubation time in the control group and the experimental group was 17.23 卤1.14) and 13.74 卤1.02 min, respectively. The mean arterial pressure in the control group and the experimental group was 97.64 卤9.34) and 90.13 卤7.32)mm 路min, respectively. The heart rate in the control group and the experimental group was 86.34 卤5.27) and 78.46 卤6.47)time -1 7.32)mm / min, respectively. The scores of sedation and restlessness in control group and test group were 5.03 卤0.45 and 3.49 卤0.17, respectively. Visual analogue score (VAS) was 4.23 卤0.24 and 2.11 卤0.16, respectively, and the difference was statistically significant (all P 0.05). The adverse drug reactions in the control group were dizziness, nausea and vomiting, and the incidence of adverse drug reactions was 11.54 / 0.24, while the adverse drug reactions in the experimental group were nausea and vomiting. The incidence of adverse drug reactions was 7.69 / 2 / 26 cases with no significant difference (P 0.05). Conclusion compared with fentanyl combined with dizosin, there is no significant difference in the incidence of adverse drug reactions. Propofol combined with dizosin can significantly reduce the restlessness and pain in the recovery period of patients undergoing general anesthesia, stabilize the mean arterial pressure and heart rate during extubation, and do not prolong the time of recovery and extubation.
【作者单位】：复旦大学附属华山医院北院麻醉科;
【分类号】：R614.2

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