Meek皮肤移植与微粒皮肤移植修复大面积深度烧伤创面效果与临床应用价值的Meta分析

发布时间：2018-03-26 08:07

本文选题：烧伤创面　切入点：Meek植皮　出处：《南昌大学》2017年硕士论文

【摘要】：背景:大面积深度烧伤病人大部分皮肤被破坏,烧伤创面暴露于外界,急需自体皮肤移植,但这类病人的自体移植皮源匮乏,Meek植皮与微粒皮植皮是救治这类烧伤病人的主要手段,近十年以来,关于Meek植皮术的临床疗效陆续被报道,但是与微粒皮植皮的临床对照研究的优劣势存在争议,这些研究大部分样本量小,缺乏说服力。目的:Meek植皮术与微粒皮植皮术在修复大面积深度烧伤创面的临床疗效及应用价值进行系统性评价。方法:用计算机以“Meek micrografting technique”AND“microskin graft methods”等为检索词检索PubMed(1990/2016-10)、Ovid(1966/2016-10)、Elsevier(1988/2016-10)、SPRINGER(1995/2016-10)、The Cochrane Library(1978/2016-10)数据库,以“Meek植皮”和“微粒皮”及“烧伤/burn”为关键检索词检索万方数据库(1982/2016)、维普中文科技期刊数据库(1979/2016)和中国知网数据库(CNKI,1979/2016),并挑选并收集与Meek植皮术与微粒皮植皮术相关治疗大面积深度烧伤创面的临床对照研究(CCT)。评价纳入研究的文献质量,关键资料收集后,使用RevMan 5.1软件行Meta分析。结果与结论:共纳入8个临床对照研究,包含302例大面积烧伤患者。相比于微粒皮植皮组,Meek植皮组在皮片存活率显著增加,在创面愈合时间、皮片融合时间、手术操作时间及1%烧伤面积治疗费用均明显降低,表明Meek植皮术比微粒皮植皮术更能明显增加皮片存活率并促进创面愈合,缩短手术操作时间,并且减少治疗费用,在临床应用价值更加有优势。
[Abstract]:Background: large area deep burn patients are mostly damaged, the burn wounds are exposed to the outside world, and autologous skin transplantation is urgently needed. However, Meek skin grafts and microskin grafts are the main methods to treat these burn patients. In the past ten years, the clinical effects of Meek skin grafting have been reported one after another. But there is controversy about the merits and demerits of clinical comparative studies with microskin grafts, most of which are small in size. Objective: to evaluate systematically the clinical efficacy and application value of Meek Meek skin grafting and microskin skin grafting in the repair of large area deep burn wounds. Methods: the computer was used to search the database of the Cochrane Library 1978-10 using "Meek micrografting technique" AND "microskin graft methods". Using "Meek skin grafting" and "Particle skin" and "Burn / Burn" as the key keywords to search Wanfang Database / 1982 / 2016, Weipu Chinese Science and Technology Journal Database / 1979 / 2016) and China knowledge Network Database to select and collect the images of Meek skin grafting and Particle skin grafting. A clinical controlled study on the treatment of large area deep burn wounds by Guan. Evaluation of the quality of literature included in the study. After the key data were collected, Meta analysis was performed with RevMan 5.1 software. Results and conclusion: eight clinical controlled studies were conducted, including 302 patients with large area burn. The survival rate of skin grafts in the Meek skin graft group was significantly higher than that in the microskin graft group. The time of wound healing, the time of skin graft fusion, the time of operation and the cost of treatment of 1% burn area were significantly decreased. The results showed that Meek skin grafting could significantly increase the survival rate of skin grafts and promote wound healing. Shortening the time of operation and reducing the cost of treatment is more valuable in clinical application.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R644

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