心脏外科手术中深低温停循环时间对患者肺功能及血清炎症因子水平的影响

发布时间：2018-03-27 13:31

  本文选题：肺功能　切入点：深低温停循环　出处：《山东医药》2017年39期

【摘要】：目的观察心脏外科手术深低温停循环时间对患者肺功能及血清炎症因子水平的影响。方法进行体外循环心脏外科手术治疗的患者40例,根据停循环时间不同分为观察组和对照组各20例。对照组中低温体循环术中深低温停循环时间≥40 min,观察组深低温停循环时间40 min。分别于手术前后检测两组患者的肺功能指标用力肺活量[(FVC%)、1秒用力呼气容积(FEV1%)]及炎症因子指标(hs-CRP、IL-6、TNF-α)。结果两组患者术后FVC%、FEV1%较术前降低,但观察组高于对照组(P均0.05)。两组术后血IL-6、TNF-α、hs-CRP水平较术前降低,且观察组低于对照组(P均0.05)。结论中低温体外循环术中深低温停循环时间40 min较≥40 min能够有效减轻肺损伤,减轻炎症反应。
[Abstract]:Objective to observe the effect of deep hypothermia circulatory arrest time on pulmonary function and serum inflammatory factor level in patients undergoing cardiopulmonary bypass (CPB). According to the time of circulatory arrest, the patients in the control group were divided into two groups: the control group (n = 20) and the control group (n = 20). The deep hypothermic circulatory arrest time in the control group was more than 40 min, and that in the observation group was 40 min. The two groups were examined before and after operation. Objective: forced vital capacity (FVC1) and inflammatory cytokines (hs-CRPIL-6, TNF- 伪) were measured. Results the FEV1% of patients in the two groups were decreased after operation. However, the levels of serum IL-6 TNF- 伪 hs-CRP in the observation group were lower than those in the control group, and the levels of serum IL-6 TNF- 伪 hs-CRP in the observation group were lower than those in the control group (P < 0.05). Conclusion the deep hypothermia cardiopulmonary bypass duration of 40 min during moderate hypothermia cardiopulmonary bypass is more effective than that of 鈮，

本文编号：1671717