吲哚美辛预防髋臼骨折术后异位骨化的疗效分析

发布时间：2018-03-27 15:11

  本文选题：异位骨化　切入点：髋臼骨折　出处：《中国矫形外科杂志》2017年10期

【摘要】：[目的]探讨吲哚美辛在预防髋臼骨折术后异位骨化中的作用。[方法]回顾性分析本院自2009年1月~2012年1月收治的120例采用Kocher-Langenbeck入路治疗的髋臼骨折病例,将上述患者随机分为两组,无药物组患者60例,术后无任何药物干预,吲哚美辛组患者60例,术后1d开始口服吲哚美辛,25 mg/次,3次/d,持续4周;术后门诊随访X线片并记录异位骨化发生情况,随访时间最短6个月,最长18个月。[结果]在所有的患者中,异位骨化发生率为49%,其中Brooker Ⅰ级16例,Ⅱ级18例,Ⅲ级15例,Ⅳ级10例,18例患者有症状,4例需要再次手术。吲哚美辛组与无药物组相比,轻度异位骨化发生率明显降低,但重度异位骨化的发生率无明显差异。[结论]髋臼骨折术后应用吲哚美辛并不能有效预防重度异位骨化的发生,应提高医生手术技巧,降低发生率。
[Abstract]:[objective] to investigate the role of indomethacin in preventing heterotopic ossification after acetabular fracture. [methods] 120 cases of acetabular fracture treated by Kocher-Langenbeck approach from January 2009 to January 2012 were retrospectively analyzed. The above patients were randomly divided into two groups: 60 patients without drugs and 60 patients with indomethacin after operation. The patients in the indomethacin group received 25 mg/ / d of indomethacin orally for 4 weeks. The incidence of ectopic ossification was 49.Results the incidence of ectopic ossification was 49,16 Brooker 鈪，

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