破骨细胞相关MicroRNA研究进展

发布时间：2018-03-28 08:15

本文选题：微小RNA　切入点：破骨细胞　出处：《动物医学进展》2017年02期

【摘要】：MicroRNA(miRNA)是一种非编码蛋白RNA,其长度约为22nt,广泛存在于真核生物细胞中,在生物的生长、发育和疾病发生等生物学过程中发挥着重要作用。随着对miRNA研究的不断深入,其在骨代谢方面的研究也逐渐展开。作为体内唯一一种负责骨吸收的细胞,破骨细胞(OC)在机体骨组织生理及病理性过程中占有重要地位。OC的形成和分化受多种因素调节,研究发现多种miRNA对OC有着调控作用,如miR-21、miR-422a和miR-148a能够促进OC形成,miR-124、miR-155和miR-503则抑制OC形成,除此以外,某些miRNA还能通过OC调控肿瘤骨转移。对这些机制的研究将从另一个层面揭示代谢性骨病的病因,并对临床治疗提供指导。论文对miRNA在OC形成和分化过程中的作用及机制进行综述。
[Abstract]:MicroRNAs miRNAs are a kind of non-coding protein RNAs, whose length is about 22nt.It widely exists in eukaryotic cells and plays an important role in biological processes such as biological growth, development and disease occurrence. As the only cell in the body responsible for bone resorption, osteoclasts (OCCs) play an important role in the physiological and pathological processes of bone tissue. The formation and differentiation of OC are regulated by many factors. It has been found that many kinds of miRNA can regulate OC, such as miR-21 miR-422a and miR-148a can promote OC formation miR-124 miR-155 and miR-503 inhibit OC formation. Some miRNA can also regulate bone metastasis through OC. The study of these mechanisms will reveal the etiology of metabolic osteopathy on another level. The role and mechanism of miRNA in the process of OC formation and differentiation were reviewed.
【作者单位】：扬州大学兽医学院;江苏省动物重要疫病与人兽共患病防控协同创新中心;
【基金】：国家自然科学基金项目(31672620,31372495,31302154) 江苏省高校自然科学基金项目(13KJB230002) 高等学校博士学科点专项科研基金项目(20133250120002) 江苏高校优势学科建设工程资助项目
【分类号】：R681

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