酒精对股骨头局部微环境影响的机制研究进展

发布时间：2018-03-29 04:34

本文选题：股骨头坏死　切入点：成骨细胞　出处：《中国组织工程研究》2017年07期

【摘要】：背景:酒精性股骨头坏死的发病机制目前尚不明确。目的:介绍股骨头微环境的生理结构和酒精致股骨头微环境的病理变化,综述酒精对股骨头微环境影响的研究现状。方法:应用计算机检索1990至2016年中国知网及PubMed数据库关于酒精对股骨头局部微环境影响的临床及实验文献报道,归纳综述酒精性股骨头坏死的病理过程。结果与结论:酒精性股骨头坏死的发病机制目前有多种学说,但其本质均为股骨头骨组织的血液循环障碍,骨的营养物质和氧供减少,骨组织、细胞长期缺氧而发生变性、坏死。大剂量酒精摄入可引起氧化-抗氧化系统失衡,严重影响股骨头局部血运环境。氧环境改变加速股骨头坏死,骨髓间充质干细胞成骨分化能力减弱,骨吸收与骨形成的平衡遭到破坏,最终加剧股骨头的坏死与骨结构塌陷。通过调控股骨头微环境的改变有望为延缓或阻止早期股骨头坏死病变进程提供新的治疗策略。
[Abstract]:Background: the pathogenesis of alcoholic femoral head necrosis is unclear. Objective: to introduce the physiological structure of the femoral head microenvironment and the pathological changes of the fine wine femoral head microenvironment. Methods: the present situation of the research on the effect of alcohol on the microenvironment of the femoral head was reviewed. Methods: the clinical and experimental reports on the effects of alcohol on the local microenvironment of the femoral head were retrieved by computer from 1990 to 2016 in China and PubMed database. Results and conclusion: there are many theories on the pathogenesis of alcoholic femoral head necrosis, but its essence is the blood circulation disturbance of femoral head tissue and the decrease of nutrition and oxygen supply of bone. Bone tissue, cells denatured and necrotized by hypoxia for a long time. High dose alcohol intake can cause imbalance of oxidation-antioxidation system, and seriously affect local blood delivery environment of femoral head. Changes of oxygen environment accelerate necrosis of femoral head. The osteogenic differentiation ability of bone marrow mesenchymal stem cells was weakened and the balance between bone resorption and bone formation was destroyed. Finally, the necrosis of the femoral head and the collapse of the bone structure are aggravated. By regulating the changes of the microenvironment of the femoral head, it is expected to provide a new treatment strategy for delaying or preventing the process of the early osteonecrosis of the femoral head.
【作者单位】：广西中医药大学;广西壮族自治区人民医院骨科;
【基金】：硕士研究生科研创新项目(YJS201651) 2014年广西自然科学基金项目(2014jj AA40654)~~
【分类号】：R681.8

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