踝关节软骨厚度影响因素的研究

发布时间：2018-03-31 10:14

本文选题：身高　切入点：体重　出处：《吉林大学》2015年硕士论文

【摘要】：目的：这篇文章主要是研究身高、体重、年龄、BMI、性别对于踝关节软骨厚度的影响，并通过与膝关节软骨厚度变化趋势的影响进行对比，分析其相同之处及不同之处，并分析其内在原因。材料与方法：从2011年1月份至2014年12月份，共有145名患者在吉林大学中日联谊医院进行踝关节核磁共振检查，通过严格的筛选，没有踝关节软骨损伤的患者被作为踝关节软骨正常人进行入组，共有99个患者满足我们的纳入标准。我们使用踝关节核磁共振图像来进行踝关节软骨厚度的测量，以身高与踝关节软骨厚度之间的关系、体重与踝关节软骨厚度之间的关系、BMI与踝关节软骨厚度之间的关系、年龄与踝关节软骨厚度之间的关系分别制作散点图，并以身高、体重、年龄为自变量，以踝关节软骨厚度为因变量做多元线性回归分析；以BMI为自变量，以踝关节软骨厚度为因变量做一元线性回归分析。为了进一步分析BMI与踝关节软骨厚度之间的关系，我们将患者样本分为体重超重组和体重正常组，对两组踝关节平均软骨厚度进行t检验分析。为了研究性别对踝关节软骨厚度的影响，并去除掉身高对于踝关节厚度的影响，我们选取身高在160cm至170cm之间的患者样本，按性别分为两组，，对两组平均软骨厚度进行t检验。结果：按照多元线性回归分析以及一元线性回归分析的结果，只有身高与踝关节软骨厚度之间有相关性（P＜0.01），并成正相关。体重、BMI、年龄与踝关节软骨厚度之间没有相关性（P＞0.05）。踝关节软骨厚度在体重正常组（18.5BMI24）与体重超重组（BMI＞24）之间并没有统计学差异（P＞0.05）。当患者身高限定在160cm至170cm之间时，男女两组身高和踝关节软骨厚度都由统计学差异（P＜0.05）。为了平衡掉身高对于踝关节软骨厚度的影响，我们限制男性组最高身高170cm，并不限制男性组最低身高；女性组不限制最高身高，最低身高设定在160cm。这时，两组身高仍有统计学差异（P＜0.05）。因此我们逐次提高女性组最低身高限制，我们尝试161cm和162cm，当女性最低身高限制在162cm时两组身高没有统计学差异（P＞0.05），因此我们将男性最高身高限制在170cm，女性最低身高限制在162cm，此时两组无论身高和软骨厚度均没有统计学差异（P＞0.05）结论：踝关节软骨厚度主要和身高有关，跟体重、年龄、BMI、性别都没有相关性。这表明，踝关节软骨厚度主要是由发育决定的，并不会随年龄的增长有明显的磨损。由于踝关节软骨与膝关节软骨的生物力学特性与生物化学特性不同，因此踝关节骨关节炎患病率并不会像膝关节那样随着年龄增长而增大。男性与女性的踝关节软骨厚度没有明显差异，因此男性和女性的踝关节骨关节炎患病率没有明显差异。
[Abstract]:Objective:. This article mainly studies the influence of height, weight, age and sex on the thickness of ankle cartilage, and analyzes its similarities and differences by comparing with the change trend of cartilage thickness of knee joint. And analyze its internal reason. Materials and methods:. From January 2011 to December 2014, 145 patients underwent an MRI examination of the ankle joint at the Sino-Japanese Friendship Hospital of Jilin University, and passed strict screening. Patients without ankle cartilage injuries were included as normal ankle cartilage, and 99 patients met our inclusion criteria. We used MRI images to measure the thickness of ankle cartilage. The relationship between height and the thickness of ankle cartilage, the relationship between weight and thickness of ankle cartilage, and the relationship between BMI and thickness of ankle cartilage, the relationship between age and thickness of ankle cartilage, and the relationship between age and the thickness of ankle cartilage were made. Weight, age as independent variables, ankle cartilage thickness as dependent variable for multiple linear regression analysis, BMI as independent variable, In order to further analyze the relationship between BMI and ankle cartilage thickness, we divided the patients into overweight and normal weight groups. In order to study the influence of height on the thickness of ankle cartilage and remove the influence of height on the thickness of ankle joint, we selected a sample of patients whose height was between 160cm and 170cm. Two groups were divided into two groups according to sex. T test was performed on the mean cartilage thickness of the two groups. Results:. According to the results of multivariate linear regression analysis and univariate linear regression analysis, There was only a correlation between height and the thickness of ankle cartilage (P < 0.01) and a positive correlation. There was no correlation between age and cartilage thickness of ankle joint (P > 0.05). The thickness of ankle cartilage was found between normal weight group (18.5BMI24) and overweight BMI > 24 (P > 24). There was no statistical difference (P > 0.05). When the height of the patient was between 160cm and 170cm, In order to balance the effect of height on the thickness of ankle cartilage, we limited the maximum height of the male group to 170 cm, not the minimum height of the male group; the female group did not limit the maximum height. The minimum height was set at 160 cm. At this time, there was still a significant difference in height between the two groups (P < 0.05). So we raised the minimum height limit of the female group one by one. We tried 161cm and 162cm, when the minimum height of women was limited to 162cm, there was no significant difference in height between the two groups (P > 0.05), so we limited the maximum height of men to 170 cm and the minimum height of women to 162 cm. In this case, both groups were of both height and cartilage thickness. There was no statistical difference (P > 0.05). Conclusion:. The thickness of ankle cartilage is mainly related to height, but not to weight, age and sex. This indicates that the thickness of ankle cartilage is mainly determined by development. There is no obvious wear with age. Because the biomechanical and biochemical properties of ankle cartilage and knee cartilage are different, Therefore, the incidence of ankle osteoarthritis does not increase with age as the knee joint. There is no significant difference in the thickness of ankle cartilage between men and women, so there is no significant difference between men and women in the prevalence of ankle osteoarthritis.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R684.3

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