右美托咪定对异丙酚和琥珀胆碱诱导插管和呼吸恢复的影响

发布时间：2018-04-01 14:17

本文选题：右美托咪定　切入点：异丙酚　出处：《四川大学学报(医学版)》2017年02期

【摘要】：目的观察预注右美托咪定对异丙酚和琥珀胆碱诱导插管和呼吸恢复的影响。方法选择60例拟行择期手术患者,随机分为右美托咪定组(D组)或生理盐水组(C组),每组30例。麻醉前分别泵注1μg/kg右美托咪定或生理盐水,在静脉注射异丙酚和琥珀胆碱后实施气管插管,插管后不行辅助通气,直至患者自主呼吸恢复。观察患者的气管插管条件、自主呼吸恢复时间、不同时点的血流动力学和脑电双频指数(BIS)变化。结果 D组有更多患者气管插管条件判为优秀,但两组总体插管条件和呼吸恢复时间差异无统计学意义(P0.05)。C组插管后即刻平均动脉压(MAP)、心率(HR)较干预前的基础值升高,差异有统计学意义(P0.01);D组插管后即刻MAP、HR与基础值相比,差异无统计学意义(P0.05)。两组患者插管后即刻的MAP和HR均较插管前增加,差异有统计学意义(P0.05)。组间比较,D组插管后即刻的MAP和HR低于C组,差异有统计学意义(P0.01)。两组患者麻醉诱导后各时点的BIS值均较基础值显著降低,D组降低幅度更大,差异有统计学意义(P0.01)。结论预注1μg/kg右美托咪定可提供更加优秀的气管插管条件且血流动力学更平稳,同时不影响患者的呼吸恢复时间。
[Abstract]:Objective to observe the effects of dexmetidine on intubation and respiratory recovery induced by propofol and succinylcholine.Methods A total of 60 patients were randomly divided into two groups: group D (group D) or group C (n = 30).Before anesthesia, 1 渭 g/kg dexmetidine or normal saline were injected respectively. After intravenous injection of propofol and succinylcholine, tracheal intubation was performed.The condition of tracheal intubation, the recovery time of spontaneous respiration, hemodynamics and bispectral index (BIS) of EEG at different time points were observed.Results the tracheal intubation conditions in group D were better than those in group D, but there was no significant difference in total intubation conditions and respiratory recovery time between the two groups. In group C, the mean arterial pressure immediately after intubation was significantly higher than that before intervention.There was no significant difference in MAPHR between the two groups immediately after intubation compared with the basic value. There was no significant difference between the two groups (P 0.05).The MAP and HR after intubation in the two groups were higher than those before intubation, and the difference was statistically significant (P 0.05).The MAP and HR of group D were lower than that of group C immediately after intubation, and the difference was statistically significant (P 0.01).The BIS value of group D was significantly lower than that of group D at each time point after anesthesia induction, and the difference was statistically significant (P 0.01).Conclusion preinjection of 1 渭 g/kg dexmetidine can provide better tracheal intubation conditions and stable hemodynamics without affecting the respiratory recovery time of the patients.
【作者单位】：四川大学华西第二医院麻醉科出生缺陷与相关妇儿疾病教育部重点实验室;
【基金】：成都市科技局(No.2014-HM01-00051-SF)资助
【分类号】：R614

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