椎间盘生物学及细胞表型的研究进展

发布时间：2018-04-02 15:15

  本文选题：椎间盘　切入点：脊索　出处：《东南大学学报(医学版)》2017年06期

【摘要】：椎间盘退变是腰背痛的主要原因,研究椎间盘发育、退变,结构功能以及椎间盘中各种细胞的特异性标志物有助于椎间盘疾病的治疗。近年来的研究发现,椎间盘起源于脊索,椎间盘退变始于髓核细胞类型和数量的改变,同时也伴随着纤维环细胞和终板软骨细胞的改变。髓核细胞有相对系统的标志物,而纤维环细胞和终板软骨细胞尚无明确的标志物。作者就椎间盘的生物学特征以及椎间盘内各种细胞标志物的研究进展作一综述。
[Abstract]:Disc degeneration is the main cause of low back pain. The study of disc development degeneration structure and function as well as the specific markers of various cells in intervertebral disc is helpful to the treatment of intervertebral disc disease.In recent years, it has been found that the disc originated from the spinal cord, and the degeneration of the intervertebral disc began with the changes of the type and quantity of nucleus pulposus cells, as well as the changes of fibroannular cells and endplate chondrocytes.There are relatively systematic markers in nucleus pulposus cells, but there are no clear markers in fibroannular cells and endplate chondrocytes.This paper reviews the biological characteristics of intervertebral disc and the progress of various cellular markers in intervertebral disc.
【作者单位】： 东南大学医学院;东南大学附属中大医院脊柱外科;
【基金】：国家自然科学基金资助项目(81572170)
【分类号】：R681.53
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本文编号：1700959