右美托咪啶和咪达唑仑用于程序化镇静疗效和安全性的系统评价

发布时间：2018-04-08 18:47

本文选题：右美托咪啶　切入点：咪达唑仑　出处：《吉林大学学报(医学版)》2017年04期

【摘要】：目的:系统评价右美托咪定和咪达唑仑用于程序化镇静时的疗效和安全性。方法:计算机检索PubMed、EMBase、Cochrane Library、CNKI、CBM和万方等数据库,全面收集右美托咪啶和咪达唑仑用于程序化镇静效果比较的临床随机对照试验(RCT),检索时限为建库至2017年3月。根据纳入标准筛选文献,并进行数据提取和质量评价,对研究结局进行系统评价。疗效结局指标为患者和医生的满意度评分、疼痛评分;安全性结局指标为低血压、低氧血症、循环和呼吸系统等并发症的发生率。结果:最终纳入14项RCT,共949例患者。与咪达唑仑组比较,右美托咪啶组患者的疼痛、谵妄发生率及镇痛需求比较差异均有统计学意义(P0.05);但呼吸抑制和低血压发生率比较差异无统计学意义(P0.05)。结论:成年患者镇静时,右美托咪定可以作为咪达唑仑镇静的理想替代药物。
[Abstract]:Objective: to evaluate the efficacy and safety of dexmetomidine and midazolam in programmed sedation.Methods: a computer-based database was retrieved from PubMeden EMBUS Cochrane Library CBM and Wanfang. The clinical randomized controlled trials of dexmetomidine and midazolam for comparison of programmed sedation effects were collected. The search time limit was until March 2017.According to the inclusion of the criteria to screen the literature, and data extraction and quality evaluation, the results of the study were systematically evaluated.The outcome of the treatment was evaluated by patients' and doctors' satisfaction and pain, and the safety outcome was the incidence of complications such as hypotension, hypoxemia, circulation and respiratory system.Results: a total of 949 patients were included in 14 RCTs.Compared with midazolam group, the incidence of pain, delirium and analgesic demand were significantly different in dexmetidine group, but there was no significant difference in incidence of respiratory depression and hypotension.Conclusion: dexmetomidine may be an ideal alternative for midazolam sedation in adult patients.
【作者单位】：郑州大学第一附属医院综合ICU河南省重症医学重点实验室;
【基金】：国家自然科学基金面上项目资助课题(81370364) 河南省教育厅高校科技创新团队资助课题(16IRTSTHN021) 河南省卫计委卫生科技创新人才资助课题(豫卫科2010-52);河南省卫计委医学科技攻关省级共建项目资助课题(201301005)
【分类号】：R614

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